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dc.contributor.author
De Palma, Giada
dc.contributor.author
Nadal, Inmaculada
dc.contributor.author
Medina, Marcela Susana
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dc.contributor.author
Donat, Ester
dc.contributor.author
Ribes Koninckx, Carmen
dc.contributor.author
Calabuig, Miguel
dc.contributor.author
Sanz, Yolanda
dc.date.available
2018-09-07T19:26:48Z
dc.date.issued
2010-02-24
dc.identifier.citation
De Palma, Giada; Nadal, Inmaculada; Medina, Marcela Susana; Donat, Ester; Ribes Koninckx, Carmen; et al.; Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children; BioMed Central; BMC Microbiology; 10; 63; 24-2-2010; 1-7
dc.identifier.issn
1471-2180
dc.identifier.uri
http://hdl.handle.net/11336/58811
dc.description.abstract
Background. Coeliac disease is a chronic intestinal inflammatory disorder due to an aberrant immune response to dietary gluten proteins in genetically predisposed individuals. Mucosal immune response through IgA secretion constitutes a first line of defence responsible for neutralizing noxious antigens and pathogens. The aim of this study was the characterization of the relationships between immunoglobulin-coated bacteria and bacterial composition of faeces of coeliac disease (CD) patients, untreated and treated with a gluten-free diet (GFD) and healthy controls. Results. IgA-coated faecal bacterial levels were significantly lower in both untreated and treated CD patients than in healthy controls. IgG and IgM-coated bacterial levels were also significantly lower in treated CD patients than in untreated CD patients and controls. Gram-positive to Gram-negative bacteria ratio was significantly reduced in both CD patients compared to controls. Bifidobacterium, Clostridium histolyticum, C. lituseburense and Faecalibacterium prausnitzii group proportions were less abundant (P < 0.050) in untreated CD patients than in healthy controls. Bacteroides-Prevotella group proportions were more abundant (P < 0.050) in untreated CD patients than in controls. Levels of IgA coating the Bacteroides-Prevotella group were significantly reduced (P < 0.050) in both CD patients in comparison with healthy controls. Conclusions. In CD patients, reduced IgA-coated bacteria is associated with intestinal dysbiosis, which altogether provide new insights into the possible relationships between the gut microbiota and the host defences in this disorder.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
BioMed Central
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Celiac Disease
dc.subject
Probiotic
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Immunoglobulin-Coated Bacteria
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Bifidobacteria
dc.subject.classification
Salud Ocupacional
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-04-10T14:05:29Z
dc.identifier.eissn
1471-2180
dc.journal.volume
10
dc.journal.number
63
dc.journal.pagination
1-7
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: De Palma, Giada. Consejo Superior de Investigaciones Científicas. Instituto de Agroquímica y Tecnología de Alimentos; España
dc.description.fil
Fil: Nadal, Inmaculada. Consejo Superior de Investigaciones Científicas. Instituto de Agroquímica y Tecnología de Alimentos; España
dc.description.fil
Fil: Medina, Marcela Susana. Consejo Superior de Investigaciones Científicas. Instituto de Agroquímica y Tecnología de Alimentos; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
dc.description.fil
Fil: Donat, Ester. Hospital Universitario La Fe de Valencia; España
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Fil: Ribes Koninckx, Carmen. Hospital Universitario La Fe de Valencia; España
dc.description.fil
Fil: Calabuig, Miguel. Hospital General Universitario de Valencia; España
dc.description.fil
Fil: Sanz, Yolanda. Consejo Superior de Investigaciones Científicas. Instituto de Agroquímica y Tecnología de Alimentos; España
dc.journal.title
BMC Microbiology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1186/1471-2180-10-63
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://bmcmicrobiol.biomedcentral.com/articles/10.1186/1471-2180-10-63
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