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Artículo

Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children

De Palma, Giada; Nadal, Inmaculada; Medina, Marcela SusanaIcon ; Donat, Ester; Ribes Koninckx, Carmen; Calabuig, Miguel; Sanz, Yolanda
Fecha de publicación: 24/02/2010
Editorial: BioMed Central
Revista: BMC Microbiology
ISSN: 1471-2180
e-ISSN: 1471-2180
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Salud Ocupacional

Resumen

Background. Coeliac disease is a chronic intestinal inflammatory disorder due to an aberrant immune response to dietary gluten proteins in genetically predisposed individuals. Mucosal immune response through IgA secretion constitutes a first line of defence responsible for neutralizing noxious antigens and pathogens. The aim of this study was the characterization of the relationships between immunoglobulin-coated bacteria and bacterial composition of faeces of coeliac disease (CD) patients, untreated and treated with a gluten-free diet (GFD) and healthy controls. Results. IgA-coated faecal bacterial levels were significantly lower in both untreated and treated CD patients than in healthy controls. IgG and IgM-coated bacterial levels were also significantly lower in treated CD patients than in untreated CD patients and controls. Gram-positive to Gram-negative bacteria ratio was significantly reduced in both CD patients compared to controls. Bifidobacterium, Clostridium histolyticum, C. lituseburense and Faecalibacterium prausnitzii group proportions were less abundant (P < 0.050) in untreated CD patients than in healthy controls. Bacteroides-Prevotella group proportions were more abundant (P < 0.050) in untreated CD patients than in controls. Levels of IgA coating the Bacteroides-Prevotella group were significantly reduced (P < 0.050) in both CD patients in comparison with healthy controls. Conclusions. In CD patients, reduced IgA-coated bacteria is associated with intestinal dysbiosis, which altogether provide new insights into the possible relationships between the gut microbiota and the host defences in this disorder.
Palabras clave: Celiac Disease , Probiotic , Immunoglobulin-Coated Bacteria , Bifidobacteria
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/58811
DOI: http://dx.doi.org/10.1186/1471-2180-10-63
URL: https://bmcmicrobiol.biomedcentral.com/articles/10.1186/1471-2180-10-63
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Articulos(CERELA)
Articulos de CENTRO DE REFERENCIA PARA LACTOBACILOS (I)
Citación
De Palma, Giada; Nadal, Inmaculada; Medina, Marcela Susana; Donat, Ester; Ribes Koninckx, Carmen; et al.; Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children; BioMed Central; BMC Microbiology; 10; 63; 24-2-2010; 1-7
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