Mostrar el registro sencillo del ítem
dc.contributor.author
Palazzolo, Martín Alejandro
dc.contributor.author
Mascotti, María Laura
dc.contributor.author
Lewkowicz, Elizabeth Sandra
dc.contributor.author
Kurina Sanz, Marcela Beatriz
dc.date.available
2016-05-26T18:33:46Z
dc.date.issued
2015-10
dc.identifier.citation
Palazzolo, Martín Alejandro; Mascotti, María Laura; Lewkowicz, Elizabeth Sandra; Kurina Sanz, Marcela Beatriz; Self-sufficient redox biotransformation of lignin-related benzoic acids with Aspergillus flavus; Springer; Journal of Industrial Microbiology & Biotechnology; 42; 12; 10-2015; 1581-1589
dc.identifier.issn
1367-5435
dc.identifier.uri
http://hdl.handle.net/11336/5843
dc.description.abstract
Aromatic carboxylic acids are readily obtained from lignin in biomass processing facilities. However, efficient technologies for lignin valorization are missing. In this work, a microbial screening was conducted to find versatile biocatalysts capable of transforming several benzoic acids structurally related to lignin, employing vanillic acid as model substrate. The wild-type Aspergillus flavus growing cells exhibited exquisite selectivity towards the oxidative decarboxylation product, 2-methoxybenzene-1,4-diol. Interestingly, when assaying a set of structurally-related substrates, the biocatalyst displayed the oxidative removal of the carboxyl moiety or its reduction to the primary alcohol whether electron withdrawing or donating groups were present in the aromatic ring, respectively. Additionally, A. flavus proved to be highly tolerant to vanillic acid increasing concentrations (up to 8 g/L), demonstrating its potential application in chemical synthesis. A. flavus growing cells were found to be efficient biotechnological tools to perform self-sufficient, structure-dependent redox reactions. All the biotransformations described herein are reported for the first time.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Benzoic
dc.subject
Redox Biotransformation
dc.subject
Aspergillus Flavus
dc.subject
Acids Carboxyl Reduction
dc.subject
Oxidative Decarboxylation
dc.subject.classification
Bioprocesamiento Tecnológico, Biocatálisis, Fermentación
dc.subject.classification
Biotecnología Industrial
dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
dc.title
Self-sufficient redox biotransformation of lignin-related benzoic acids with Aspergillus flavus
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-05-16T20:09:58Z
dc.journal.volume
42
dc.journal.number
12
dc.journal.pagination
1581-1589
dc.journal.pais
Alemania
dc.journal.ciudad
Heidelberg
dc.description.fil
Fil: Palazzolo, Martín Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones En Tecnología Química; Argentina
dc.description.fil
Fil: Mascotti, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones en Tecnología Química; Argentina
dc.description.fil
Fil: Lewkowicz, Elizabeth Sandra. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnologia; Argentina
dc.description.fil
Fil: Kurina Sanz, Marcela Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones En Tecnología Química; Argentina
dc.journal.title
Journal of Industrial Microbiology & Biotechnology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs10295-015-1696-4
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s10295-015-1696-4
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/10.1007/s10295-015-1696-4
Archivos asociados