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dc.contributor.author
Coronel, Camila Denise  
dc.contributor.author
Arce, Gabriel  
dc.contributor.author
Iglesias, Cesar  
dc.contributor.author
Magallanes Noguera, Cynthia Alejandra  
dc.contributor.author
Rodriguez Bonnecarrere, Paula  
dc.contributor.author
Rodriguez Giordano, Sonia  
dc.contributor.author
Gonzales, David  
dc.date.available
2016-05-24T18:54:43Z  
dc.date.issued
2014-02-07  
dc.identifier.citation
Coronel, Camila Denise; Arce, Gabriel; Iglesias, Cesar; Magallanes Noguera, Cynthia Alejandra; Rodriguez Bonnecarrere, Paula; et al.; Chemoenzymatic synthesis of fluoxetine precursors. Reduction of β-substituted propiophenones; Elsevier; Journal of Molecular Catalysis B: Enzymatic; 102; 7-2-2014; 94-98  
dc.identifier.issn
1381-1177  
dc.identifier.uri
http://hdl.handle.net/11336/5815  
dc.description.abstract
Five endophytic yeast strains isolated from edible plants were tested in the reduction β-chloro- and β-azidopropiophenone for the preparation of optically active fluoxetine precursors. The biotransformation rendered not only the corresponding chiral γ-substituted alcohols, but also unsubstituted alcohols and ketones. The product profile was studied and a plausible mechanism for the reductive elimination of the β-functional group is proposed.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/  
dc.subject
Endophytes  
dc.subject
Fluoxetine  
dc.subject
B-Substituted Ketone  
dc.subject.classification
Química Orgánica  
dc.subject.classification
Ciencias Químicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Chemoenzymatic synthesis of fluoxetine precursors. Reduction of β-substituted propiophenones  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2016-05-16T20:06:39Z  
dc.journal.volume
102  
dc.journal.pagination
94-98  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Coronel, Camila Denise. Universidad de la Republica; Uruguay  
dc.description.fil
Fil: Arce, Gabriel. Universidad de la Republica; Uruguay  
dc.description.fil
Fil: Iglesias, Cesar. Universidad de la Republica; Uruguay  
dc.description.fil
Fil: Magallanes Noguera, Cynthia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones en Tecnología Química; Argentina  
dc.description.fil
Fil: Rodriguez Bonnecarrere, Paula. Universidad de la Republica; Uruguay  
dc.description.fil
Fil: Rodriguez Giordano, Sonia. Universidad de la Republica; Uruguay  
dc.description.fil
Fil: Gonzales, David. Universidad de la Republica; Uruguay  
dc.journal.title
Journal of Molecular Catalysis B: Enzymatic  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1381117714000332  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.molcatb.2014.01.022  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.molcatb.2014.01.022  

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