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dc.contributor.author
Laborde, Evangelina Andrea
dc.contributor.author
Vanzulli, Silvia
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Beigier Bompadre, Macarena
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Isturiz, Martín Amadeo
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Ruggiero, Raul Alejandro
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Fourcade, Mariano G.
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Catalan Pellet, Antonio C.
dc.contributor.author
Sozzani, Silvano
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Vulcano, Marisa
dc.date.available
2018-08-29T09:33:53Z
dc.date.issued
2007-07-01
dc.identifier.citation
Laborde, Evangelina Andrea; Vanzulli, Silvia; Beigier Bompadre, Macarena; Isturiz, Martín Amadeo; Ruggiero, Raul Alejandro; et al.; Immune complexes inhibit differentiation, maturation, and function of human monocyte-derived dendritic cells; American Association of Immunologists; Journal of Immunology; 179; 1; 1-7-2007; 673-681
dc.identifier.issn
0022-1767
dc.identifier.uri
http://hdl.handle.net/11336/57500
dc.description.abstract
The interaction between immune complexes (IC) and the receptors for the Fc portion of IgG (Fc Rs) triggers regulatory and effector functions in the immune system. In this study, we investigated the effects of IC on differentiation, maturation, and functions of human monocyte-derived dendritic cells (DC). When IC were added on day 0, DC generated on day 6 (IC-DC) showed lower levels of CD1a and increased expression of CD14, MHC class II, and the macrophage marker CD68, as compared with normally differentiated DC. The use of specific blocking Fc R mAbs indicated that the effect of IC was exerted mainly through their interaction with Fc RI and to a lesser extend with Fc RII. Immature IC-DC also expressed higher levels of CD83, CD86, and CD40 and the expression of these maturation markers was not further regulated by LPS. The apparent lack of maturation following TLR stimulation was associated with a decreased production of IL-12, normal secretion of IL-10 and CCL22, and increased production of CXCL8 and CCL2. IC-DC displayed low endocytic activity and a reduced ability to induce allogeneic T cell proliferation both at basal and LPS-stimulated conditions. Altogether, these data reveal that IC strongly affect DC differentiation and maturation. Skewing of DC function from Ag presentation to a proinflammatory phenotype by IC resembles the state of activation observed in DC obtained from patients with chronic inflammatory autoimmune disorders, such as systemic lupus erythematosus disease and arthritis. Therefore, the altered maturation of DC induced by IC may be involved in the pathogenesis of autoimmune diseases.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Association of Immunologists
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Antigen Antibody
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Cell Differentiation
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Dendritic Cells
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Lupus Erythematosus
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Monocytes
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Receptors Igg
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Medicina General e Interna
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Immune complexes inhibit differentiation, maturation, and function of human monocyte-derived dendritic cells
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-08-13T18:47:03Z
dc.journal.volume
179
dc.journal.number
1
dc.journal.pagination
673-681
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Bethesda
dc.description.fil
Fil: Laborde, Evangelina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
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Fil: Vanzulli, Silvia. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología ; Argentina
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Fil: Beigier Bompadre, Macarena. Academia Nacional de Medicina de Buenos Aires; Argentina
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Fil: Isturiz, Martín Amadeo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
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Fil: Ruggiero, Raul Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
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Fil: Fourcade, Mariano G.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos Bernardino Rivadavia; Argentina
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Fil: Catalan Pellet, Antonio C.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos Bernardino Rivadavia; Argentina
dc.description.fil
Fil: Sozzani, Silvano. Universita Degli Studi Di Brescia; Italia
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Fil: Vulcano, Marisa. Humanitas Research Hospital; . Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.journal.title
Journal of Immunology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4049/jimmunol.179.1.673
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.jimmunol.org/content/179/1/673.long
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/17579090
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