Repositorio Institucional
Repositorio Institucional
CONICET Digital
  • Inicio
  • EXPLORAR
    • AUTORES
    • DISCIPLINAS
    • COMUNIDADES
  • Estadísticas
  • Novedades
    • Noticias
    • Boletines
  • Ayuda
    • General
    • Datos de investigación
  • Acerca de
    • CONICET Digital
    • Equipo
    • Red Federal
  • Contacto
JavaScript is disabled for your browser. Some features of this site may not work without it.
  • INFORMACIÓN GENERAL
  • RESUMEN
  • ESTADISTICAS
 
Artículo

Immune complexes inhibit differentiation, maturation, and function of human monocyte-derived dendritic cells

Laborde, Evangelina AndreaIcon ; Vanzulli, Silvia; Beigier Bompadre, Macarena; Isturiz, Martín AmadeoIcon ; Ruggiero, Raul AlejandroIcon ; Fourcade, Mariano G.; Catalan Pellet, Antonio C.; Sozzani, Silvano; Vulcano, MarisaIcon
Fecha de publicación: 01/07/2007
Editorial: American Association of Immunologists
Revista: Journal of Immunology
ISSN: 0022-1767
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Medicina General e Interna

Resumen

The interaction between immune complexes (IC) and the receptors for the Fc portion of IgG (Fc Rs) triggers regulatory and effector functions in the immune system. In this study, we investigated the effects of IC on differentiation, maturation, and functions of human monocyte-derived dendritic cells (DC). When IC were added on day 0, DC generated on day 6 (IC-DC) showed lower levels of CD1a and increased expression of CD14, MHC class II, and the macrophage marker CD68, as compared with normally differentiated DC. The use of specific blocking Fc R mAbs indicated that the effect of IC was exerted mainly through their interaction with Fc RI and to a lesser extend with Fc RII. Immature IC-DC also expressed higher levels of CD83, CD86, and CD40 and the expression of these maturation markers was not further regulated by LPS. The apparent lack of maturation following TLR stimulation was associated with a decreased production of IL-12, normal secretion of IL-10 and CCL22, and increased production of CXCL8 and CCL2. IC-DC displayed low endocytic activity and a reduced ability to induce allogeneic T cell proliferation both at basal and LPS-stimulated conditions. Altogether, these data reveal that IC strongly affect DC differentiation and maturation. Skewing of DC function from Ag presentation to a proinflammatory phenotype by IC resembles the state of activation observed in DC obtained from patients with chronic inflammatory autoimmune disorders, such as systemic lupus erythematosus disease and arthritis. Therefore, the altered maturation of DC induced by IC may be involved in the pathogenesis of autoimmune diseases.
Palabras clave: Antigen Antibody , Cell Differentiation , Dendritic Cells , Lupus Erythematosus , Monocytes , Receptors Igg
Ver el registro completo
 
Archivos asociados
Thumbnail
 
Tamaño: 335.9Kb
Formato: PDF
.
Descargar
Licencia
info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/57500
DOI: http://dx.doi.org/10.4049/jimmunol.179.1.673
URL: http://www.jimmunol.org/content/179/1/673.long
Colecciones
Articulos(IMEX)
Articulos de INST.DE MEDICINA EXPERIMENTAL
Citación
Laborde, Evangelina Andrea; Vanzulli, Silvia; Beigier Bompadre, Macarena; Isturiz, Martín Amadeo; Ruggiero, Raul Alejandro; et al.; Immune complexes inhibit differentiation, maturation, and function of human monocyte-derived dendritic cells; American Association of Immunologists; Journal of Immunology; 179; 1; 1-7-2007; 673-681
Compartir
Altmétricas
 

Enviar por e-mail
Separar cada destinatario (hasta 5) con punto y coma.
  • Facebook
  • X Conicet Digital
  • Instagram
  • YouTube
  • Sound Cloud
  • LinkedIn

Los contenidos del CONICET están licenciados bajo Creative Commons Reconocimiento 2.5 Argentina License

https://www.conicet.gov.ar/ - CONICET

Inicio

Explorar

  • Autores
  • Disciplinas
  • Comunidades

Estadísticas

Novedades

  • Noticias
  • Boletines

Ayuda

Acerca de

  • CONICET Digital
  • Equipo
  • Red Federal

Contacto

Godoy Cruz 2290 (C1425FQB) CABA – República Argentina – Tel: +5411 4899-5400 repositorio@conicet.gov.ar
TÉRMINOS Y CONDICIONES