Artículo
Role of polymorphonuclear leukocytes in the pathophysiology of typical hemolytic uremic syndrome
Fecha de publicación:
08/2007
Editorial:
HINDAWI publishing Corporation
Revista:
Scientific World Journal
ISSN:
1537-744X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Thrombotic microangiopathy and acute renal failure are cardinal features of post-diarrheal hemolytic uremic syndrome (HUS). These conditions are related to endothelial and epithelial cell damage induced by Shiga toxin (Stx), through an interaction with its globotriaosylceramide (Gb3) receptor. Although, Stx is the main pathogenic factor and necessary for HUS development, clinical and experimental evidence suggest that the inflammatory response is able to potentiate Stx toxicity. Lipopolysaccharides (LPS) and neutrophils (PMN) represent two central components of inflammation during a Gram-negative infection. In this regard, patients with high peripheral PMN counts at presentation have a poor prognosis. In the present review, we discuss the contribution of experimental models and patient's studies in an attempt to elucidate the pathogenic mechanisms of HUS. ©2007 with author. Published by TheScientificWorld.
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Articulos(IMEX)
Articulos de INST.DE MEDICINA EXPERIMENTAL
Articulos de INST.DE MEDICINA EXPERIMENTAL
Citación
Exeni, Ramón A.; Fernández, Gabriela Cristina; Palermo, Marina Sandra; Role of polymorphonuclear leukocytes in the pathophysiology of typical hemolytic uremic syndrome; HINDAWI publishing Corporation; Scientific World Journal; 7; 8-2007; 1155-1164
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