Artículo

Regio-specific synthesis of new 1-(tert-butyl)-1H-pyrazolecarboxamide derivatives

Ruatta Merke, Santiago Matías; Murguia, Marcelo CesarIcon ; Ramírez de Arellano, Carmen; Fustero, Santos
Fecha de publicación: 06/2017
Editorial: Pergamon-Elsevier Science Ltd
Revista: Tetrahedron Letters
ISSN: 0040-4039
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

Regio-specific and non-regiospecific condensation reactions on 1,3-dicarbonyl compounds rendered 1,3,5-trisubstituted pyrazoles. Herein, the control of regio-specificity was a significant improvement in pyrazole research. A high yield acylation of poorly nucleophilic aryl amines, which resulted in mono- or diacylated products depending on the reaction conditions, is described. As a result, a library of potentially bioactive compounds was obtained.
Palabras clave: Arylamine Acylation , Diacylation , Pyrazole Carboxamide , Regio-Specific Condensation , Tert-Butyl Hydrazine
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/55666
DOI: http://dx.doi.org/10.1016/j.tetlet.2017.05.029
URL: https://www.sciencedirect.com/science/article/pii/S004040391730607X
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Articulos(INTEC)
Articulos de INST.DE DES.TECNOL.PARA LA IND.QUIMICA (I)
Citación
Ruatta Merke, Santiago Matías; Murguia, Marcelo Cesar; Ramírez de Arellano, Carmen; Fustero, Santos; Regio-specific synthesis of new 1-(tert-butyl)-1H-pyrazolecarboxamide derivatives; Pergamon-Elsevier Science Ltd; Tetrahedron Letters; 58; 25; 6-2017; 2441-2444
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