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dc.contributor.author
Mendez, J. A.
dc.contributor.author
Aguilar, M. R.
dc.contributor.author
Abraham, Gustavo Abel
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dc.contributor.author
Vazquez, B.
dc.contributor.author
Dalby, M.
dc.contributor.author
Di Silvio, L.
dc.contributor.author
San Roman, J.
dc.date.available
2018-08-13T15:32:42Z
dc.date.issued
2002-11
dc.identifier.citation
Mendez, J. A.; Aguilar, M. R.; Abraham, Gustavo Abel; Vazquez, B.; Dalby, M.; et al.; New acrylic bone cements conjugated to vitamin E: Curing parameters, properties, and biocompatibility; Wiley; Journal Of Biomedical Materials Research; 62; 2; 11-2002; 299-307
dc.identifier.issn
0021-9304
dc.identifier.uri
http://hdl.handle.net/11336/55121
dc.description.abstract
Acrylic bone cement formulations with antioxidant character were prepared by incorporation of a methacrylic monomer derived from vitamin E (MVE). Increasing concentrations of this monomer provided decreasing peak temperature values, ranging from 62 to 36°C, and increasing setting time with values between 17 and 25 min. Mechanical properties were evaluated by compression and tension tests. Compressive strength of the new formulations were superior to 70 MPa in all cases. The cement containing 25 wt % MVE, however, showed a significant decrease in tensile properties. Biocompatibility of the new formulations was studied in vitro. The analysis of the effect of leachables from cements into the media showed continued cell proliferation and cell viability with a significant increase for the cement containing 15 wt % MVE. This formulation also showed a significant increase in cellular proliferation over a period of 7 days as indicated by the Alamar Blue test. The cells were able to differentiate and express phenotypical markers in presence of all materials. A significant increase in alkaline phosphatase activity was observed on the cements prepared in presence of 15-25 wt % MVE compared with PMMA. Morphological assessment showed that the human osteoblast (HOB) cells were able to adhere, retain their morphology, and proliferate on all the cements. © 2002 Wiley Periodicals, Inc.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Acrylic Bone Cements
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Biocompatibility
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Biological Evaluation
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In Vitro Testing
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Vitamin e Derivative
dc.subject.classification
Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
New acrylic bone cements conjugated to vitamin E: Curing parameters, properties, and biocompatibility
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-07-11T17:27:06Z
dc.journal.volume
62
dc.journal.number
2
dc.journal.pagination
299-307
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Hoboken
dc.description.fil
Fil: Mendez, J. A.. Consejo Superior de Investigaciones Científicas; España
dc.description.fil
Fil: Aguilar, M. R.. Consejo Superior de Investigaciones Científicas; España
dc.description.fil
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Consejo Superior de Investigaciones Científicas; España
dc.description.fil
Fil: Vazquez, B.. Consejo Superior de Investigaciones Científicas; España
dc.description.fil
Fil: Dalby, M.. IRC in Biomedical Materials; Reino Unido
dc.description.fil
Fil: Di Silvio, L.. IRC in Biomedical Materials; Reino Unido
dc.description.fil
Fil: San Roman, J.. Consejo Superior de Investigaciones Científicas; España
dc.journal.title
Journal Of Biomedical Materials Research
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1002/jbm.10296
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.10296
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