Artículo
New acrylic bone cements conjugated to vitamin E: Curing parameters, properties, and biocompatibility
Mendez, J. A.; Aguilar, M. R.; Abraham, Gustavo Abel
; Vazquez, B.; Dalby, M.; Di Silvio, L.; San Roman, J.
Fecha de publicación:
11/2002
Editorial:
Wiley
Revista:
Journal Of Biomedical Materials Research
ISSN:
0021-9304
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Acrylic bone cement formulations with antioxidant character were prepared by incorporation of a methacrylic monomer derived from vitamin E (MVE). Increasing concentrations of this monomer provided decreasing peak temperature values, ranging from 62 to 36°C, and increasing setting time with values between 17 and 25 min. Mechanical properties were evaluated by compression and tension tests. Compressive strength of the new formulations were superior to 70 MPa in all cases. The cement containing 25 wt % MVE, however, showed a significant decrease in tensile properties. Biocompatibility of the new formulations was studied in vitro. The analysis of the effect of leachables from cements into the media showed continued cell proliferation and cell viability with a significant increase for the cement containing 15 wt % MVE. This formulation also showed a significant increase in cellular proliferation over a period of 7 days as indicated by the Alamar Blue test. The cells were able to differentiate and express phenotypical markers in presence of all materials. A significant increase in alkaline phosphatase activity was observed on the cements prepared in presence of 15-25 wt % MVE compared with PMMA. Morphological assessment showed that the human osteoblast (HOB) cells were able to adhere, retain their morphology, and proliferate on all the cements. © 2002 Wiley Periodicals, Inc.
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(INTEMA)
Articulos de INST.DE INV.EN CIENCIA Y TECNOL.MATERIALES (I)
Articulos de INST.DE INV.EN CIENCIA Y TECNOL.MATERIALES (I)
Citación
Mendez, J. A.; Aguilar, M. R.; Abraham, Gustavo Abel; Vazquez, B.; Dalby, M.; et al.; New acrylic bone cements conjugated to vitamin E: Curing parameters, properties, and biocompatibility; Wiley; Journal Of Biomedical Materials Research; 62; 2; 11-2002; 299-307
Compartir
Altmétricas