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dc.contributor.author
Mañas, Fernando Javier
dc.contributor.author
Peralta, Laura
dc.contributor.author
Raviolo, Jose Maria
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Garcia Ovando, Hugo
dc.contributor.author
Weyers, Irma Alicia
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Ugnia, Laura Inés
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Gonzalez Cid, Marcela Beatriz
dc.contributor.author
Larripa, Irene Beatriz
dc.contributor.author
Gorla, Nora Bibiana Maria
dc.date.available
2018-08-09T17:34:39Z
dc.date.issued
2009-07
dc.identifier.citation
Mañas, Fernando Javier; Peralta, Laura; Raviolo, Jose Maria; Garcia Ovando, Hugo; Weyers, Irma Alicia; et al.; Genotoxicity of glyphosate assessed by the comet assay and cytogenetic tests; Elsevier Science; Environmental Toxicology and Pharmacology; 28; 1; 7-2009; 37-41
dc.identifier.issn
1382-6689
dc.identifier.uri
http://hdl.handle.net/11336/54803
dc.description.abstract
It was evaluated the genotoxicity of glyphosate which up to now has heterogeneous results. The comet assay was performed in Hep-2 cells. The level of DNA damage in the control group (5.42 ± 1.83 arbitrary units) for tail moment (TM) measurements has shown a significant increase (p < 0.01) with glyphosate at a range concentration from 3.00 to 7.50 mM. In the chromosome aberrations (CA) test in human lymphocytes the herbicide (0.20-6.00 mM) showed no significant effects in comparison with the control group. In vivo, the micronucleus test (MNT) was evaluated in mice at three doses rendering statistical significant increases at 400 mg/kg (13.0 ± 3.08 micronucleated erythrocytes/1000 cells, p < 0.01). In the present study glyphosate was genotoxic in the comet assay in Hep-2 cells and in the MNT test at 400 mg/kg in mice. Thiobarbituric acid reactive substances (TBARs) levels, superoxide dismutase (SOD) and catalase (CAT) activities were quantified in their organs. The results showed an increase in these enzyme activities. © 2009 Elsevier B.V. All rights reserved.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Catalase
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Chromosome Aberrations
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Comet Assay
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Glyphosate
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Micronucleus
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Sod
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Tbars
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Toxicología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Genotoxicity of glyphosate assessed by the comet assay and cytogenetic tests
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-08-06T21:40:50Z
dc.journal.volume
28
dc.journal.number
1
dc.journal.pagination
37-41
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Mañas, Fernando Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
dc.description.fil
Fil: Peralta, Laura. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
dc.description.fil
Fil: Raviolo, Jose Maria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
dc.description.fil
Fil: Garcia Ovando, Hugo. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
dc.description.fil
Fil: Weyers, Irma Alicia. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
dc.description.fil
Fil: Ugnia, Laura Inés. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
dc.description.fil
Fil: Gonzalez Cid, Marcela Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.description.fil
Fil: Larripa, Irene Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.description.fil
Fil: Gorla, Nora Bibiana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
dc.journal.title
Environmental Toxicology and Pharmacology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.etap.2009.02.001
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1382668909000258
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