Artículo
Pediocin-like bacteriocins: new perspectives on mechanism of action and immunity
Ríos Colombo, Natalia Soledad
; Chalon, Miriam Carolina
; Navarro, Silvia Adriana
; Bellomio, Augusto
![Icon](/themes/CONICETDigital/images/conicet.png)
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Fecha de publicación:
04/2018
Editorial:
Springer
Revista:
Current Genetics
ISSN:
0172-8083
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
This review attempts to analyze the mechanism of action and immunity of class IIa bacteriocins. These peptides are promising alternative food preservatives and they have a great potential application in medical sciences. Class IIa bacteriocins act on the cytoplasmic membrane of Gram-positive cells dissipating the transmembrane electrical potential by forming pores. However, their toxicity and immunity mechanism remains elusive. Here we discuss the role of the mannose phosphotransferase system (man-PTS) as the receptor for class IIa bacteriocins and the influence of the membrane composition on the activity of these antimicrobial peptides. A model that is consistent with experimental results obtained by different researchers involves the non-specific binding of the bacteriocin to the negatively charged membrane of target bacteria. This step would facilitate a specific binding to the receptor protein, altering its functionality and forming an independent pore in which the bacteriocin is inserted in the membrane. An immunity protein could specifically recognize and block the pore. Bacteriocins function in bacterial ecosystems and energetic costs associated with their production are also discussed. Theoretical models based on solid experimental evidence are vital to understand bacteriocins mechanism of action and to promote new technological developments.
Palabras clave:
Bacteriocin
,
Immunity Protein
,
Man-Pts
,
Mechanism of Action
,
Membrane
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Articulos(INSIBIO)
Articulos de INST.SUP.DE INVEST.BIOLOGICAS
Articulos de INST.SUP.DE INVEST.BIOLOGICAS
Citación
Ríos Colombo, Natalia Soledad; Chalon, Miriam Carolina; Navarro, Silvia Adriana; Bellomio, Augusto; Pediocin-like bacteriocins: new perspectives on mechanism of action and immunity; Springer; Current Genetics; 64; 2; 4-2018; 345-351
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