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Artículo

Identification of new palmitoylated proteins in Toxoplasma gondii

Caballero, MarinaIcon ; Alonso, Andrés MarianoIcon ; Deng, Bin; Attias, Marcia; De Souza, Wanderley; Corvi, Maria MarthaIcon
Fecha de publicación: 04/2016
Editorial: Elsevier Science
Revista: Biochimica Et Biophysica Acta-proteins And Proteomics
ISSN: 1570-9639
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Biológicas

Resumen

Protein palmitoylation has been shown to be an important post-translational modification in eukaryotic cells. This modification alters the localization and/or the function of the targeted protein. In recent years, protein palmitoylation has risen in importance in apicomplexan parasites as well. In Toxoplasma gondii, some proteins have been reported to be modified by palmitate. With the development of new techniques that allow the isolation of palmitoylated proteins, this significant post-translational modification has begun to be studied in more detail in T. gondii. Here we describe the palmitoylome of the tachyzoite stage of T. gondii using a combination of the acyl-biotin exchange chemistry method and mass spectrometry analysis. We identified 401 proteins found in multiple cellular compartments, with a wide range of functions that vary from metabolic processes, gliding and host-cell invasion to even regulation of transcription and translation. Besides, we found that more rhoptry proteins than the ones already described for Toxoplasma are palmitoylated, suggesting an important role for this modification in the invasion mechanism of the host-cell. This study documents that protein palmitoylation is a common modification in T. gondii that could have an impact on different cellular processes.
Palabras clave: Acyl-Biotin Exchange , Host-Cell Invasion , Palmitoylome , Protein Identification , Rhoptry , Toxoplasma Gondii
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/53623
DOI: http://dx.doi.org/10.1016/j.bbapap.2016.01.010
URL: https://www.sciencedirect.com/science/article/pii/S1570963916300024
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857766/
Colecciones
Articulos(CCT - LA PLATA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Articulos(IIB-INTECH)
Articulos de INST.DE INVEST.BIOTECNOLOGICAS - INSTITUTO TECNOLOGICO CHASCOMUS
Citación
Caballero, Marina; Alonso, Andrés Mariano; Deng, Bin; Attias, Marcia; De Souza, Wanderley; et al.; Identification of new palmitoylated proteins in Toxoplasma gondii; Elsevier Science; Biochimica Et Biophysica Acta-proteins And Proteomics; 1864; 4; 4-2016; 400-408
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