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dc.contributor.author
Silva, Marta G.
dc.contributor.author
Ueti, Massaro W.
dc.contributor.author
Norimine, Junzo
dc.contributor.author
Jacobsen, Monica Ofelia
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dc.contributor.author
Bastos, Reginaldo G.
dc.contributor.author
Goff, Will L.
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Brown, Wendy C.
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Oliva, Abel
dc.contributor.author
Suarez, Carlos E.
dc.date.available
2018-07-31T14:16:19Z
dc.date.issued
2010-06
dc.identifier.citation
Silva, Marta G.; Ueti, Massaro W.; Norimine, Junzo; Jacobsen, Monica Ofelia; Bastos, Reginaldo G.; et al.; Babesia bovis expresses a neutralization-sensitive antigen that contains a microneme adhesive repeat (MAR) domain; Elsevier Ireland; Parasitology International; 59; 2; 6-2010; 294-297
dc.identifier.issn
1383-5769
dc.identifier.uri
http://hdl.handle.net/11336/53570
dc.description.abstract
A gene coding for a protein with sequence similarity to the Toxoplasma gondii micronemal 1 (MIC1) protein that contains a copy of a domain described as a sialic acid-binding micronemal adhesive repeat (MAR) was identified in the Babesia bovis genome. The single copy gene, located in chromosome 3, contains an open reading frame encoding a putative 181 amino acid protein, which is highly conserved among distinct B. bovis strains. Antibodies against both recombinant protein and synthetic peptides mimicking putative antigenic regions in the B. bovis-MIC1 (Bbo-MIC1) protein bind to the parasite in immunofluorescence assays and significantly inhibit erythrocyte invasion in in vitro B. bovis cultures. Bbo-MIC1 is recognized by antibodies in serum from B. bovis infected cattle, demonstrating expression and immunogenicity during infection. Overall, the results suggest that Bbo-MIC1 protein is a viable candidate for development of subunit vaccines. © 2010 Elsevier Ireland Ltd.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Ireland
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Babesia Bovis
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Bbo-Mic1
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In Vitro Neutralization Assay
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Mic Proteins
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Micronemes
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Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Babesia bovis expresses a neutralization-sensitive antigen that contains a microneme adhesive repeat (MAR) domain
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-07-30T15:40:41Z
dc.journal.volume
59
dc.journal.number
2
dc.journal.pagination
294-297
dc.journal.pais
Irlanda
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dc.description.fil
Fil: Silva, Marta G.. Universidade Nova de Lisboa; Portugal
dc.description.fil
Fil: Ueti, Massaro W.. Animal Disease Research Unit; Estados Unidos
dc.description.fil
Fil: Norimine, Junzo. Washington State University; Estados Unidos
dc.description.fil
Fil: Jacobsen, Monica Ofelia. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Bastos, Reginaldo G.. Washington State University; Estados Unidos
dc.description.fil
Fil: Goff, Will L.. Animal Disease Research Unit; Estados Unidos
dc.description.fil
Fil: Brown, Wendy C.. Washington State University; Estados Unidos
dc.description.fil
Fil: Oliva, Abel. Universidade Nova de Lisboa; Portugal
dc.description.fil
Fil: Suarez, Carlos E.. Animal Disease Research Unit; Estados Unidos
dc.journal.title
Parasitology International
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.parint.2010.03.004
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1383576910000577
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