Artículo
Babesia bovis expresses a neutralization-sensitive antigen that contains a microneme adhesive repeat (MAR) domain
Silva, Marta G.; Ueti, Massaro W.; Norimine, Junzo; Jacobsen, Monica Ofelia
; Bastos, Reginaldo G.; Goff, Will L.; Brown, Wendy C.; Oliva, Abel; Suarez, Carlos E.
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Fecha de publicación:
06/2010
Editorial:
Elsevier Ireland
Revista:
Parasitology International
ISSN:
1383-5769
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
A gene coding for a protein with sequence similarity to the Toxoplasma gondii micronemal 1 (MIC1) protein that contains a copy of a domain described as a sialic acid-binding micronemal adhesive repeat (MAR) was identified in the Babesia bovis genome. The single copy gene, located in chromosome 3, contains an open reading frame encoding a putative 181 amino acid protein, which is highly conserved among distinct B. bovis strains. Antibodies against both recombinant protein and synthetic peptides mimicking putative antigenic regions in the B. bovis-MIC1 (Bbo-MIC1) protein bind to the parasite in immunofluorescence assays and significantly inhibit erythrocyte invasion in in vitro B. bovis cultures. Bbo-MIC1 is recognized by antibodies in serum from B. bovis infected cattle, demonstrating expression and immunogenicity during infection. Overall, the results suggest that Bbo-MIC1 protein is a viable candidate for development of subunit vaccines. © 2010 Elsevier Ireland Ltd.
Palabras clave:
Babesia Bovis
,
Bbo-Mic1
,
In Vitro Neutralization Assay
,
Mic Proteins
,
Micronemes
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Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Silva, Marta G.; Ueti, Massaro W.; Norimine, Junzo; Jacobsen, Monica Ofelia; Bastos, Reginaldo G.; et al.; Babesia bovis expresses a neutralization-sensitive antigen that contains a microneme adhesive repeat (MAR) domain; Elsevier Ireland; Parasitology International; 59; 2; 6-2010; 294-297
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