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dc.contributor.author
Mortarino, P. A.  
dc.contributor.author
Goy, D. P.  
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Abramson, D. B.  
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Cabello, J.  
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Bumaguin, G. E.  
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Vitelli, E. J.  
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Toledo, J.  
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Sarrio, L.  
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Pezzotto, Stella Maris  
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Mardegan Issa, J.P.  
dc.contributor.author
Cointry, Gustavo Roberto  
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Feldman, Sara  
dc.date.available
2018-07-27T15:08:41Z  
dc.date.issued
2016-02  
dc.identifier.citation
Mortarino, P. A.; Goy, D. P.; Abramson, D. B.; Cabello, J.; Bumaguin, G. E.; et al.; Emerging therapy in arthritis: Modulation of markers of the inflammatory process; Wiley-liss, Div John Wiley & Sons Inc; Microscopy Research And Technique.; 79; 2; 2-2016; 89-97  
dc.identifier.issn
1059-910X  
dc.identifier.uri
http://hdl.handle.net/11336/53293  
dc.description.abstract
The induction of tolerance has been proposed as a therapeutic strategy for arthritis aiming to decrease progression of the pathology, probably by promoting suppressor mechanisms of the autoimmune response. This work aimed to confirm whether the treatment with vitamin D3 could synergize oral tolerance induced by hydrolyzed collagen peptides, in our experimental model of antigen induced arthritis in New Zealand rabbits. Clinical observation of the phenomenon indicates that simultaneous treatment with hydrolyzed collagen peptides and vitamin D3 was beneficial when compared with no treatment, for arthritic animals, and for arthritic animals that received treatment with only hydrolyzed collagen peptides or vitamin D3. Treatment with hydrolyzed collagen peptides caused diminished proinflammatory cytokine levels, an effect synergized significantly by the simultaneous treatment with vitamin D3. The anatomical-pathological studies of the animals that received both treatments simultaneously showed synovial tissues without lymphocytic and plasma cell infiltrates, and without vascular proliferation. Some of the synovial tissue of the animals of these groups showed a slight decrease in Galectin-3 expression. We propose that simultaneous oral treatment with vitamin D3 and hydrolyzed collagen peptides could increase the immunoregulatory effect on the process of previously triggered arthritis. We used articular cartilage hydrolysate and not collagen II because peptides best expose antigenic determinants that could induce oral tolerance. Oral tolerance may be considered in the design of novel alternative therapies for autoimmune disease and we have herein presented novel evidence that the simultaneous treatment with vitamin D3 may synergize this beneficial effect.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Wiley-liss, Div John Wiley & Sons Inc  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Arthritis  
dc.subject
Immunomodulation  
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Microscopy Research  
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Oral Tolerance  
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Vitamin D  
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Epidemiología  
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Ciencias de la Salud  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Emerging therapy in arthritis: Modulation of markers of the inflammatory process  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-07-24T14:47:49Z  
dc.journal.volume
79  
dc.journal.number
2  
dc.journal.pagination
89-97  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Nueva York  
dc.description.fil
Fil: Mortarino, P. A.. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina  
dc.description.fil
Fil: Goy, D. P.. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina  
dc.description.fil
Fil: Abramson, D. B.. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina  
dc.description.fil
Fil: Cabello, J.. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina  
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Fil: Bumaguin, G. E.. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina  
dc.description.fil
Fil: Vitelli, E. J.. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina  
dc.description.fil
Fil: Toledo, J.. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina  
dc.description.fil
Fil: Sarrio, L.. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina  
dc.description.fil
Fil: Pezzotto, Stella Maris. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina  
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Fil: Mardegan Issa, J.P.. Universidade de Sao Paulo; Brasil  
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Fil: Cointry, Gustavo Roberto. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina  
dc.description.fil
Fil: Feldman, Sara. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina. Consejo de Investigaciones de la Universidad Nacional de Rosario; Argentina  
dc.journal.title
Microscopy Research And Technique.  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1002/jemt.22609  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/jemt.22609