Artículo
Emerging therapy in arthritis: Modulation of markers of the inflammatory process
Mortarino, P. A.; Goy, D. P.; Abramson, D. B.; Cabello, J.; Bumaguin, G. E.; Vitelli, E. J.; Toledo, J.; Sarrio, L.; Pezzotto, Stella Maris; Mardegan Issa, J.P.; Cointry, Gustavo Roberto
; Feldman, Sara
Fecha de publicación:
02/2016
Editorial:
Wiley-liss, Div John Wiley & Sons Inc
Revista:
Microscopy Research And Technique.
ISSN:
1059-910X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The induction of tolerance has been proposed as a therapeutic strategy for arthritis aiming to decrease progression of the pathology, probably by promoting suppressor mechanisms of the autoimmune response. This work aimed to confirm whether the treatment with vitamin D3 could synergize oral tolerance induced by hydrolyzed collagen peptides, in our experimental model of antigen induced arthritis in New Zealand rabbits. Clinical observation of the phenomenon indicates that simultaneous treatment with hydrolyzed collagen peptides and vitamin D3 was beneficial when compared with no treatment, for arthritic animals, and for arthritic animals that received treatment with only hydrolyzed collagen peptides or vitamin D3. Treatment with hydrolyzed collagen peptides caused diminished proinflammatory cytokine levels, an effect synergized significantly by the simultaneous treatment with vitamin D3. The anatomical-pathological studies of the animals that received both treatments simultaneously showed synovial tissues without lymphocytic and plasma cell infiltrates, and without vascular proliferation. Some of the synovial tissue of the animals of these groups showed a slight decrease in Galectin-3 expression. We propose that simultaneous oral treatment with vitamin D3 and hydrolyzed collagen peptides could increase the immunoregulatory effect on the process of previously triggered arthritis. We used articular cartilage hydrolysate and not collagen II because peptides best expose antigenic determinants that could induce oral tolerance. Oral tolerance may be considered in the design of novel alternative therapies for autoimmune disease and we have herein presented novel evidence that the simultaneous treatment with vitamin D3 may synergize this beneficial effect.
Palabras clave:
Arthritis
,
Immunomodulation
,
Microscopy Research
,
Oral Tolerance
,
Vitamin D
Archivos asociados
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Identificadores
Colecciones
Articulos(CCT - ROSARIO)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - ROSARIO
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - ROSARIO
Citación
Mortarino, P. A.; Goy, D. P.; Abramson, D. B.; Cabello, J.; Bumaguin, G. E.; et al.; Emerging therapy in arthritis: Modulation of markers of the inflammatory process; Wiley-liss, Div John Wiley & Sons Inc; Microscopy Research And Technique.; 79; 2; 2-2016; 89-97
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