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dc.contributor.author
Coraglia, Ana Carina
dc.contributor.author
Felippo, Marta Elena
dc.contributor.author
Schierloh, Luis Pablo
dc.contributor.author
Malbrán, Alejandro
dc.contributor.author
González Bracco, María de las Mercedes
dc.date.available
2018-07-24T18:25:15Z
dc.date.issued
2011-12
dc.identifier.citation
Coraglia, Ana Carina; Felippo, Marta Elena; Schierloh, Luis Pablo; Malbrán, Alejandro; González Bracco, María de las Mercedes; CD4+ T Lymphocytes with follicular helper phenotype (T FH) in patients with SH2D1A deficiency (XLP); Academic Press Inc Elsevier Science; Clinical Immunology; 141; 3; 12-2011; 357-364
dc.identifier.issn
1521-6616
dc.identifier.uri
http://hdl.handle.net/11336/52976
dc.description.abstract
Peripheral blood mononuclear cells with T FH phenotype from two asymptomatic XLP patients were studied. Normal/high numbers of CXCR5+, CD4+ T cells coexpressing PD-1 were demonstrated. Peripheral blood mononuclear cells (PBMC) from these patients responded to sub-optimal PHA/IL-2 stimulation upregulating ICOS and CD40L and increasing intracellular expression of IL-10, IL-21 and IL-4 by CD4+ T FH cells. However when compared to N, the time profile of activation and cytokine synthesis was different in XLP and N. While ICOS and CD40L expression in N decreased after 6-8days, it continued to increase or was maintained in XLP cultures. Intracellular IL-10, IL-21 and IL-4 reached higher values in XLP than N after 8days. Rather than the absence of T FH cells or their intrinsic inability to respond to stimuli, differences in the time profile of their response could contribute to impair their role as helpers of B lymphocytes. © 2011 Elsevier Inc.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Academic Press Inc Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Cd40l
dc.subject
Icos
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Il-10
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Il-21
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Il-4
dc.subject
Tfh
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Xlp
dc.subject.classification
Medicina Critica y de Emergencia
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
CD4+ T Lymphocytes with follicular helper phenotype (T FH) in patients with SH2D1A deficiency (XLP)
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-07-24T14:01:56Z
dc.journal.volume
141
dc.journal.number
3
dc.journal.pagination
357-364
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Coraglia, Ana Carina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Felippo, Marta Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Schierloh, Luis Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Malbrán, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: González Bracco, María de las Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.journal.title
Clinical Immunology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.clim.2011.09.007
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1521661611002762
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