Artículo
CD4+ T Lymphocytes with follicular helper phenotype (T FH) in patients with SH2D1A deficiency (XLP)
Coraglia, Ana Carina
; Felippo, Marta Elena
; Schierloh, Luis Pablo
; Malbrán, Alejandro
; González Bracco, María de las Mercedes
Fecha de publicación:
12/2011
Editorial:
Academic Press Inc Elsevier Science
Revista:
Clinical Immunology
ISSN:
1521-6616
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Peripheral blood mononuclear cells with T FH phenotype from two asymptomatic XLP patients were studied. Normal/high numbers of CXCR5+, CD4+ T cells coexpressing PD-1 were demonstrated. Peripheral blood mononuclear cells (PBMC) from these patients responded to sub-optimal PHA/IL-2 stimulation upregulating ICOS and CD40L and increasing intracellular expression of IL-10, IL-21 and IL-4 by CD4+ T FH cells. However when compared to N, the time profile of activation and cytokine synthesis was different in XLP and N. While ICOS and CD40L expression in N decreased after 6-8days, it continued to increase or was maintained in XLP cultures. Intracellular IL-10, IL-21 and IL-4 reached higher values in XLP than N after 8days. Rather than the absence of T FH cells or their intrinsic inability to respond to stimuli, differences in the time profile of their response could contribute to impair their role as helpers of B lymphocytes. © 2011 Elsevier Inc.
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Articulos(IMEX)
Articulos de INST.DE MEDICINA EXPERIMENTAL
Articulos de INST.DE MEDICINA EXPERIMENTAL
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Coraglia, Ana Carina; Felippo, Marta Elena; Schierloh, Luis Pablo; Malbrán, Alejandro; González Bracco, María de las Mercedes; CD4+ T Lymphocytes with follicular helper phenotype (T FH) in patients with SH2D1A deficiency (XLP); Academic Press Inc Elsevier Science; Clinical Immunology; 141; 3; 12-2011; 357-364
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