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dc.contributor.author
Ruggiero, Raul Alejandro
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Bruzzo Iraola, Juan
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Chiarella, Paula
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Di Gianni, Pedro
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Isturiz, Martín Amadeo
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Linskens, Susana Beatriz
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Speziale, Norma
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Meiss, Roberto P.
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Bustuoabad, Oscar David
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Pasqualini, Christiane D.
dc.date.available
2018-07-24T14:25:44Z
dc.date.issued
2011-11
dc.identifier.citation
Ruggiero, Raul Alejandro; Bruzzo Iraola, Juan; Chiarella, Paula; Di Gianni, Pedro; Isturiz, Martín Amadeo; et al.; Tyrosine isomers mediate the classical phenomenon of concomitant tumor resistance; American Association for Cancer Research; Cancer Research; 71; 22; 11-2011; 7113-7124
dc.identifier.issn
0008-5472
dc.identifier.uri
http://hdl.handle.net/11336/52941
dc.description.abstract
Concomitant tumor resistance (CR) is a phenomenon originally described in 1906 in which a tumor-bearing host is resistant to the growth of secondary tumor implants and metastasis. Although recent studies have indicated that T-cell-dependent processes mediate CR in hosts bearing immunogenic small tumors, manifestations of CR induced by immunogenic and nonimmunogenic large tumors have been associated with an elusive serum factor. In this study, we identify this serum factor as tyrosine in its meta and ortho isoforms. In three different murine models of cancer that generate CR, both meta-tyrosine and ortho-tyrosine inhibited tumor growth. In addition, we showed that both isoforms of tyrosine blocked metastasis in a fourth model that does not generate CR but is sensitive to CR induced by other tumors. Mechanistic studies showed that the antitumor effects of the tyrosine isoforms were mediated, in part, by early inhibition of mitogen-activated protein/extracellular signal-regulated kinase pathway and inactivation of STAT3, potentially driving tumor cells into a state of dormancy. By revealing a molecular basis for the classical phenomenon of CR, our findings may stimulate new generalized approaches to limit the development of metastases that arise after resection of primary tumors, an issue of pivotal importance to oncologists and their patients. ©2011 AACR.
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application/pdf
dc.language.iso
eng
dc.publisher
American Association for Cancer Research
dc.rights
info:eu-repo/semantics/openAccess
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https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
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Concomitant Tumor Resistance
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Tyrosine Isomers
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Otras Medicina Básica
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Tyrosine isomers mediate the classical phenomenon of concomitant tumor resistance
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-07-17T20:49:37Z
dc.journal.volume
71
dc.journal.number
22
dc.journal.pagination
7113-7124
dc.journal.pais
Estados Unidos
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Philadelphia
dc.description.fil
Fil: Ruggiero, Raul Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; Argentina
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Fil: Bruzzo Iraola, Juan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; Argentina
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Fil: Chiarella, Paula. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; Argentina
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Fil: Di Gianni, Pedro. Academia Nacional de Medicina de Buenos Aires; Argentina
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Fil: Isturiz, Martín Amadeo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; Argentina
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Fil: Linskens, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
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Fil: Speziale, Norma. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
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Fil: Meiss, Roberto P.. Academia Nacional de Medicina de Buenos Aires; Argentina
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Fil: Bustuoabad, Oscar David. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.description.fil
Fil: Pasqualini, Christiane D.. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.journal.title
Cancer Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1158/0008-5472.CAN-11-0581
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info:eu-repo/semantics/altIdentifier/url/http://cancerres.aacrjournals.org/content/71/22/7113