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Artículo

Tyrosine isomers mediate the classical phenomenon of concomitant tumor resistance

Ruggiero, Raul AlejandroIcon ; Bruzzo Iraola, JuanIcon ; Chiarella, PaulaIcon ; Di Gianni, Pedro; Isturiz, Martín AmadeoIcon ; Linskens, Susana BeatrizIcon ; Speziale, Norma; Meiss, Roberto P.; Bustuoabad, Oscar DavidIcon ; Pasqualini, Christiane D.
Fecha de publicación: 11/2011
Editorial: American Association for Cancer Research
Revista: Cancer Research
ISSN: 0008-5472
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Medicina Básica

Resumen

Concomitant tumor resistance (CR) is a phenomenon originally described in 1906 in which a tumor-bearing host is resistant to the growth of secondary tumor implants and metastasis. Although recent studies have indicated that T-cell-dependent processes mediate CR in hosts bearing immunogenic small tumors, manifestations of CR induced by immunogenic and nonimmunogenic large tumors have been associated with an elusive serum factor. In this study, we identify this serum factor as tyrosine in its meta and ortho isoforms. In three different murine models of cancer that generate CR, both meta-tyrosine and ortho-tyrosine inhibited tumor growth. In addition, we showed that both isoforms of tyrosine blocked metastasis in a fourth model that does not generate CR but is sensitive to CR induced by other tumors. Mechanistic studies showed that the antitumor effects of the tyrosine isoforms were mediated, in part, by early inhibition of mitogen-activated protein/extracellular signal-regulated kinase pathway and inactivation of STAT3, potentially driving tumor cells into a state of dormancy. By revealing a molecular basis for the classical phenomenon of CR, our findings may stimulate new generalized approaches to limit the development of metastases that arise after resection of primary tumors, an issue of pivotal importance to oncologists and their patients. ©2011 AACR.
Palabras clave: Concomitant Tumor Resistance , Tyrosine Isomers
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/52941
DOI: https://dx.doi.org/10.1158/0008-5472.CAN-11-0581
URL: http://cancerres.aacrjournals.org/content/71/22/7113
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Articulos de INST.DE MEDICINA EXPERIMENTAL
Citación
Ruggiero, Raul Alejandro; Bruzzo Iraola, Juan; Chiarella, Paula; Di Gianni, Pedro; Isturiz, Martín Amadeo; et al.; Tyrosine isomers mediate the classical phenomenon of concomitant tumor resistance; American Association for Cancer Research; Cancer Research; 71; 22; 11-2011; 7113-7124
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