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Artículo

Galectin-3 is upregulated in activated glia during Junin virus-induced murine encephalitis

Jaquenod de Giusti, CarolinaIcon ; Alberdi, Maria LucreciaIcon ; Frik, JesicaIcon ; Ferrer, Maria FlorenciaIcon ; Scharrig Fernandez, Maria EmiliaIcon ; Schattner, Mirta AnaIcon ; Gomez, Ricardo MartinIcon
Fecha de publicación: 09/2011
Editorial: Elsevier Ireland
Revista: Neuroscience Letters
ISSN: 0304-3940
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Salud Ocupacional

Resumen

Argentine haemorrhagic fever (AHF) is a systemic febrile syndrome characterized by several haematological and neurological alterations caused by Junín virus (JUNV), a member of the Arenaviridae family. Newborn mice are highly susceptible to JUNV and the course of infection has been associated with the viral strain used. Galectin-3 (Gal-3) is an animal lectin that has been proposed to play an important role in some central nervous system (CNS) diseases. In this study, we analysed Gal-3 expression at the transcriptional and translational expression levels during JUNV-induced CNS disease. We found that Candid 1 strain induced, with relatively low mortality, a subacute/chronic CNS disease with significant glia activation and upregulation of Gal-3 in microglia cells as well as in reactive astrocytes that correlated with viral levels. Our results suggest an important role for Gal-3 in viral-induced CNS disease. © 2011 Elsevier Ireland Ltd.
Palabras clave: Astrocytes , Gfap , Microglia , Viral Infection
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/52929
DOI: http://dx.doi.org/10.1016/j.neulet.2011.07.007
URL: https://www.sciencedirect.com/science/article/pii/S0304394011010408
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Articulos(IMEX)
Articulos de INST.DE MEDICINA EXPERIMENTAL
Citación
Jaquenod de Giusti, Carolina; Alberdi, Maria Lucrecia; Frik, Jesica; Ferrer, Maria Florencia; Scharrig Fernandez, Maria Emilia; et al.; Galectin-3 is upregulated in activated glia during Junin virus-induced murine encephalitis; Elsevier Ireland; Neuroscience Letters; 501; 3; 9-2011; 163-166
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