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dc.contributor.author
Tagliazucchi, Enzo Rodolfo
dc.contributor.author
Chialvo, Dante Renato
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Siniatchkin, Michael
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Amico, Enrico
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Brichant, Jean Francois
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Bonhomme, Vincent
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Noirhomme, Quentin
dc.contributor.author
Laufs, Helmut
dc.contributor.author
Laureys, Steven
dc.date.available
2018-07-17T19:49:43Z
dc.date.issued
2016-01
dc.identifier.citation
Tagliazucchi, Enzo Rodolfo; Chialvo, Dante Renato; Siniatchkin, Michael; Amico, Enrico; Brichant, Jean Francois; et al.; Large-scale signatures of unconsciousness are consistent with a departure from critical dynamics; The Royal Society; Journal of the Royal Society Interface; 13; 114; 1-2016; 1-12
dc.identifier.issn
1742-5689
dc.identifier.uri
http://hdl.handle.net/11336/52509
dc.description.abstract
Loss of cortical integration and changes in the dynamics of electrophysiological brain signals characterize the transition from wakefulness towards unconsciousness. In this study, we arrive at a basic model explaining these observations based on the theory of phase transitions in complex systems. We studied the link between spatial and temporal correlations of large-scale brain activity recorded with functional magnetic resonance imaging during wakefulness, propofol-induced sedation and loss of consciousness and during the subsequent recovery. We observed that during unconsciousness activity in frontothalamic regions exhibited a reduction of long-range temporal correlations and a departure of functional connectivity from anatomical constraints. A model of a system exhibiting a phase transition reproduced our findings, as well as the diminished sensitivity of the cortex to external perturbations during unconsciousness. This framework unifies different observations about brain activity during unconsciousness and predicts that the principles we identified are universal and independent from its causes.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
The Royal Society
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Anaesthesia
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Complex Systems
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Consciousness
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Fmri
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Phase Transitions
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Otras Ciencias Físicas
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Ciencias Físicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Large-scale signatures of unconsciousness are consistent with a departure from critical dynamics
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-07-17T13:56:20Z
dc.journal.volume
13
dc.journal.number
114
dc.journal.pagination
1-12
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Christian Albrechts University zu Kiel; Alemania. Goethe Universitat Frankfurt; Alemania
dc.description.fil
Fil: Chialvo, Dante Renato. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Siniatchkin, Michael. Christian Albrechts University zu Kiel; Alemania
dc.description.fil
Fil: Amico, Enrico. Université de Liège; Bélgica
dc.description.fil
Fil: Brichant, Jean Francois. Université de Liège; Bélgica
dc.description.fil
Fil: Bonhomme, Vincent. Université de Liège; Bélgica
dc.description.fil
Fil: Noirhomme, Quentin. Université de Liège; Bélgica
dc.description.fil
Fil: Laufs, Helmut. Goethe Universitat Frankfurt; Alemania
dc.description.fil
Fil: Laureys, Steven. Université de Liège; Bélgica
dc.journal.title
Journal of the Royal Society Interface
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1098/rsif.2015.1027
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://rsif.royalsocietypublishing.org/content/13/114/20151027
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