Artículo
Large-scale signatures of unconsciousness are consistent with a departure from critical dynamics
Tagliazucchi, Enzo Rodolfo
; Chialvo, Dante Renato
; Siniatchkin, Michael; Amico, Enrico; Brichant, Jean Francois; Bonhomme, Vincent; Noirhomme, Quentin; Laufs, Helmut; Laureys, Steven
Fecha de publicación:
01/2016
Editorial:
The Royal Society
Revista:
Journal of the Royal Society Interface
ISSN:
1742-5689
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Loss of cortical integration and changes in the dynamics of electrophysiological brain signals characterize the transition from wakefulness towards unconsciousness. In this study, we arrive at a basic model explaining these observations based on the theory of phase transitions in complex systems. We studied the link between spatial and temporal correlations of large-scale brain activity recorded with functional magnetic resonance imaging during wakefulness, propofol-induced sedation and loss of consciousness and during the subsequent recovery. We observed that during unconsciousness activity in frontothalamic regions exhibited a reduction of long-range temporal correlations and a departure of functional connectivity from anatomical constraints. A model of a system exhibiting a phase transition reproduced our findings, as well as the diminished sensitivity of the cortex to external perturbations during unconsciousness. This framework unifies different observations about brain activity during unconsciousness and predicts that the principles we identified are universal and independent from its causes.
Palabras clave:
Anaesthesia
,
Complex Systems
,
Consciousness
,
Fmri
,
Phase Transitions
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Articulos(CCT - ROSARIO)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - ROSARIO
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - ROSARIO
Citación
Tagliazucchi, Enzo Rodolfo; Chialvo, Dante Renato; Siniatchkin, Michael; Amico, Enrico; Brichant, Jean Francois; et al.; Large-scale signatures of unconsciousness are consistent with a departure from critical dynamics; The Royal Society; Journal of the Royal Society Interface; 13; 114; 1-2016; 1-12
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