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dc.contributor.author
Prabhakaran, Molamma P.
dc.contributor.author
Zamani, Maedeh
dc.contributor.author
Felice, Betiana
dc.contributor.author
Ramakrishna, Seeram
dc.date.available
2018-06-28T19:26:02Z
dc.date.issued
2015-11
dc.identifier.citation
Prabhakaran, Molamma P.; Zamani, Maedeh; Felice, Betiana; Ramakrishna, Seeram; Electrospraying technique for the fabrication of metronidazole contained PLGA particles and their release profile; Elsevier Science; Materials Science and Engineering: C; 56; 11; 11-2015; 66-73
dc.identifier.issn
0928-4931
dc.identifier.uri
http://hdl.handle.net/11336/50480
dc.description.abstract
Advanced engineering of materials for the development of drug delivery devices provides scope for novel and versatile strategies for treatment of various diseases. 'Electrospraying' was used to prepare PLGA microparticles and further encapsulate the drug, metronidazole (Met) within the particles to function as a drug delivery system. Two different solvents were utilized for the preparation of drug loaded PLGA particles, whereby the polymeric solution in dichloromethane (DCM) produced particles of bigger sizes than using trifluoroethanol (TFE). Scanning electron microscopy showed the spherical morphology of the particles, with sizes of 3946 ± 407 nm and 1774 ± 167 nm, respectively for PLGA-Met(DCM) and PLGA-Met(TFE). The FTIR spectroscopy proved the incorporation of metronidazole in the polymer, but without any specific drug-polymer interaction. The release of the drug from the particles was studied in phosphate buffered saline, where a sustained drug release was obtained for at least 41 days. Cytotoxicity evaluation of the drug extract using mesenchymal stem cells (MSCs) showed not hindering the proliferation of MSCs, and the cell phenotype was retained after incubation in the drug containing media. Electrospraying is suggested as a cost-effective and single step process for the preparation of polymeric microparticles for prolonged and controlled release of drug.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Drug Delivery
dc.subject
Electrospraying
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Particle Size
dc.subject
Release
dc.subject
Stem Cells
dc.subject.classification
Recubrimientos y Películas
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Ingeniería de los Materiales
dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
dc.title
Electrospraying technique for the fabrication of metronidazole contained PLGA particles and their release profile
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-28T13:55:58Z
dc.journal.volume
56
dc.journal.number
11
dc.journal.pagination
66-73
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Prabhakaran, Molamma P.. National University Of Singapore; Singapur
dc.description.fil
Fil: Zamani, Maedeh. National University Of Singapore; Singapur
dc.description.fil
Fil: Felice, Betiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
dc.description.fil
Fil: Ramakrishna, Seeram. National University Of Singapore; Singapur
dc.journal.title
Materials Science and Engineering: C
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.msec.2015.06.018
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0928493115301478?via%3Dihub


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