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Artículo

Electrospraying technique for the fabrication of metronidazole contained PLGA particles and their release profile

Prabhakaran, Molamma P.; Zamani, Maedeh; Felice, BetianaIcon ; Ramakrishna, Seeram
Fecha de publicación: 11/2015
Editorial: Elsevier Science
Revista: Materials Science and Engineering: C
ISSN: 0928-4931
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Recubrimientos y Películas

Resumen

Advanced engineering of materials for the development of drug delivery devices provides scope for novel and versatile strategies for treatment of various diseases. 'Electrospraying' was used to prepare PLGA microparticles and further encapsulate the drug, metronidazole (Met) within the particles to function as a drug delivery system. Two different solvents were utilized for the preparation of drug loaded PLGA particles, whereby the polymeric solution in dichloromethane (DCM) produced particles of bigger sizes than using trifluoroethanol (TFE). Scanning electron microscopy showed the spherical morphology of the particles, with sizes of 3946 ± 407 nm and 1774 ± 167 nm, respectively for PLGA-Met(DCM) and PLGA-Met(TFE). The FTIR spectroscopy proved the incorporation of metronidazole in the polymer, but without any specific drug-polymer interaction. The release of the drug from the particles was studied in phosphate buffered saline, where a sustained drug release was obtained for at least 41 days. Cytotoxicity evaluation of the drug extract using mesenchymal stem cells (MSCs) showed not hindering the proliferation of MSCs, and the cell phenotype was retained after incubation in the drug containing media. Electrospraying is suggested as a cost-effective and single step process for the preparation of polymeric microparticles for prolonged and controlled release of drug.
Palabras clave: Drug Delivery , Electrospraying , Particle Size , Release , Stem Cells
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/50480
DOI: https://dx.doi.org/10.1016/j.msec.2015.06.018
URL: https://www.sciencedirect.com/science/article/pii/S0928493115301478?via%3Dihub
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Articulos(INSIBIO) [569]
Articulos de INST.SUP.DE INVEST.BIOLOGICAS
Citación
Prabhakaran, Molamma P.; Zamani, Maedeh; Felice, Betiana; Ramakrishna, Seeram; Electrospraying technique for the fabrication of metronidazole contained PLGA particles and their release profile; Elsevier Science; Materials Science and Engineering: C; 56; 11; 11-2015; 66-73
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