Artículo
Total Leishmania antigens with Poly(I:C) induce Th1 protective response
Sánchez, María Victoria; Eliçabe, Ricardo Javier
; Di Genaro, Maria Silvia
; Germano, Maria Jose
; Gea, Susana
; Garcia Bustos, Maria Fernanda
; Salomón, María Cristina; Scodeller, Eduardo
; Cargnelutti, Diego Esteban
Fecha de publicación:
11/2017
Editorial:
Wiley Blackwell Publishing, Inc
Revista:
Parasite Immunology
ISSN:
0141-9838
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Our proposal was to develop a vaccine based on total Leishmania antigens (TLA) adjuvanted with polyinosinic-polycytidylic acid [Poly(I:C)] able to induce a Th1 response which can provide protection against Leishmania infection. Mice were vaccinated with two doses of TLA-Poly(I:C) administered by subcutaneous route at 3-week interval. Humoral and cellular immune responses induced by the immunization were measured. The protective efficacy of the vaccine was evaluated by challenging mice with infective promastigotes of Leishmania (Leishmania) amazonensis into the footpad. Mice vaccinated with TLA-Poly(I:C) showed a high anti-Leishmania IgG titre, as well as increased IgG1 and IgG2a subclass titres compared with mice vaccinated with the TLA alone. The high IgG2a indicated a Th1 bias response induced by the TLA-Poly(I:C) immunization. Accordingly, the cellular immune response elicited by the formulation was characterized by an increased production of IFN-γ and no significant production of IL-4. The TLA-Poly(I:C) immunization elicited good protection, which was associated with decreased footpad swelling, a lower parasite load and a reduced histopathological alteration in the footpad. Our findings demonstrate a promising vaccine against cutaneous leishmaniasis that is relatively economic and easy to develop and which should be taken into account for preventing leishmaniasis in developing countries.
Palabras clave:
ADJUVANT
,
LEISHMANIASIS
,
PARASITE
,
VACCINATION
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Colecciones
Articulos(IMBECU)
Articulos de INST. DE MEDICINA Y BIO. EXP. DE CUYO
Articulos de INST. DE MEDICINA Y BIO. EXP. DE CUYO
Articulos(IMIBIO-SL)
Articulos de INST. MULTIDICIPLINARIO DE INV. BIO. DE SAN LUIS
Articulos de INST. MULTIDICIPLINARIO DE INV. BIO. DE SAN LUIS
Citación
Sánchez, María Victoria; Eliçabe, Ricardo Javier; Di Genaro, Maria Silvia; Germano, Maria Jose; Gea, Susana; et al.; Total Leishmania antigens with Poly(I:C) induce Th1 protective response; Wiley Blackwell Publishing, Inc; Parasite Immunology; 39; 11; 11-2017; 1-5
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