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dc.contributor.author
Renner, U.
dc.contributor.author
Sapochnik, Melanie Denis
dc.contributor.author
Lucia, K.
dc.contributor.author
Stalla, G. K.
dc.contributor.author
Arzt, Eduardo Simon
dc.date.available
2018-06-22T20:24:03Z
dc.date.issued
2017-02
dc.identifier.citation
Renner, U.; Sapochnik, Melanie Denis; Lucia, K.; Stalla, G. K.; Arzt, Eduardo Simon; Intrahypophyseal Immune-Endocrine Interactions: Endocrine Integration of the Inflammatory Inputs; Karger; Frontiers of Hormone Research; 48; 2-2017; 37-47
dc.identifier.issn
0301-3073
dc.identifier.uri
http://hdl.handle.net/11336/49778
dc.description.abstract
Endotoxin (lipopolysaccharide, LPS) of gram-negative bacteria has been recognized for more than 40 years as a modulator of anterior pituitary hormone production. The action of LPS was thought to be predominantly mediated through LPS-stimulated immune cell-derived cytokines, and is part of the concept of immune-endocrine crosstalk, which regulates bidirectional adaptive processes between the endocrine and immune systems during inflammatory or infectious processes. With the detection of innate immune system components in the normal and tumoral pituitary, including the Toll-like receptor 4, the target of LPS, it has become evident that LPS can directly modify the physiology and pathophysiology of the anterior pituitary. LPS-induced intrapituitary mechanisms involve the stimulation of intrapituitary cytokines, and also directly act on hormone synthesis, growth, and apoptosis of endocrine cells. This review focuses on the effects of LPS on pituitary physiology, its interaction with pro- and anti-inflammatory factors, and the molecular mechanisms involved in these processes.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Karger
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Pituitary Physiology
dc.subject
Lps
dc.subject.classification
Salud Ocupacional
dc.subject.classification
Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Intrahypophyseal Immune-Endocrine Interactions: Endocrine Integration of the Inflammatory Inputs
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-19T15:55:26Z
dc.journal.volume
48
dc.journal.pagination
37-47
dc.journal.pais
Suiza
dc.journal.ciudad
Basilea
dc.description.fil
Fil: Renner, U.. Max Planck Institute of Psychiatry; Alemania
dc.description.fil
Fil: Sapochnik, Melanie Denis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina
dc.description.fil
Fil: Lucia, K.. Max Planck Institute of Psychiatry; Alemania
dc.description.fil
Fil: Stalla, G. K.. Max Planck Institute of Psychiatry; Alemania
dc.description.fil
Fil: Arzt, Eduardo Simon. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología y Biología Molecular y Celular; Argentina
dc.journal.title
Frontiers of Hormone Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1159/000452904
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/Abstract/452904
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