Artículo
Intrahypophyseal Immune-Endocrine Interactions: Endocrine Integration of the Inflammatory Inputs
Fecha de publicación:
02/2017
Editorial:
Karger
Revista:
Frontiers of Hormone Research
ISSN:
0301-3073
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Endotoxin (lipopolysaccharide, LPS) of gram-negative bacteria has been recognized for more than 40 years as a modulator of anterior pituitary hormone production. The action of LPS was thought to be predominantly mediated through LPS-stimulated immune cell-derived cytokines, and is part of the concept of immune-endocrine crosstalk, which regulates bidirectional adaptive processes between the endocrine and immune systems during inflammatory or infectious processes. With the detection of innate immune system components in the normal and tumoral pituitary, including the Toll-like receptor 4, the target of LPS, it has become evident that LPS can directly modify the physiology and pathophysiology of the anterior pituitary. LPS-induced intrapituitary mechanisms involve the stimulation of intrapituitary cytokines, and also directly act on hormone synthesis, growth, and apoptosis of endocrine cells. This review focuses on the effects of LPS on pituitary physiology, its interaction with pro- and anti-inflammatory factors, and the molecular mechanisms involved in these processes.
Palabras clave:
Pituitary Physiology
,
Lps
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IBIOBA - MPSP)
Articulos de INST. D/INV.EN BIOMED.DE BS AS-CONICET-INST. PARTNER SOCIEDAD MAX PLANCK
Articulos de INST. D/INV.EN BIOMED.DE BS AS-CONICET-INST. PARTNER SOCIEDAD MAX PLANCK
Citación
Renner, U.; Sapochnik, Melanie Denis; Lucia, K.; Stalla, G. K.; Arzt, Eduardo Simon; Intrahypophyseal Immune-Endocrine Interactions: Endocrine Integration of the Inflammatory Inputs; Karger; Frontiers of Hormone Research; 48; 2-2017; 37-47
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