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dc.contributor.author
Abdelgawad, Azza
dc.contributor.author
Damiani, Armando Mario
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dc.contributor.author
Ho, Simón Y. W.
dc.contributor.author
Strauss, Gunter
dc.contributor.author
Szentiks, Claudia A.
dc.contributor.author
East, Marion L.
dc.contributor.author
Osterrieder, Nikolaus
dc.contributor.author
Alex Greenwood
dc.date.available
2018-06-22T18:58:00Z
dc.date.issued
2016-09
dc.identifier.citation
Abdelgawad, Azza; Damiani, Armando Mario; Ho, Simón Y. W.; Strauss, Gunter; Szentiks, Claudia A.; et al.; Zebra alphaherpesviruses (EHV-1 and EHV-9): Genetic diversity, Latency and co-infections; MDPI; Viruses; 8; 9; 9-2016; 1-13
dc.identifier.issn
1999-4915
dc.identifier.uri
http://hdl.handle.net/11336/49706
dc.description.abstract
Alphaherpesviruses are highly prevalent in equine populations and co-infections with more than one of these viruses’ strains frequently diagnosed. Lytic replication and latency with subsequent reactivation, along with new episodes of disease, can be influenced by genetic diversity generated by spontaneous mutation and recombination. Latency enhances virus survival by providing an epidemiological strategy for long-term maintenance of divergent strains in animal populations. The alphaherpesviruses equine herpesvirus 1 (EHV-1) and 9 (EHV-9) have recently been shown to cross species barriers, including a recombinant EHV-1 observed in fatal infections of a polar bear and Asian rhinoceros. Little is known about the latency and genetic diversity of EHV-1 and EHV-9, especially among zoo and wild equids. Here, we report evidence of limited genetic diversity in EHV-9 in zebras, whereas there is substantial genetic variability in EHV-1. We demonstrate that zebras can be lytically and latently infected with both viruses concurrently. Such a co-occurrence of infection in zebras suggests that even relatively slow-evolving viruses such as equine herpesviruses have the potential to diversify rapidly by recombination. This has potential consequences for the diagnosis of these viruses and their management in wild and captive equid populations.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
MDPI
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Co-Occurrence
dc.subject
Diversity
dc.subject
Ehv-1
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Ehv-9
dc.subject
Latency
dc.subject
Zebra
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Zebra alphaherpesviruses (EHV-1 and EHV-9): Genetic diversity, Latency and co-infections
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-18T19:08:18Z
dc.journal.volume
8
dc.journal.number
9
dc.journal.pagination
1-13
dc.journal.pais
Suiza
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dc.journal.ciudad
Basel
dc.description.fil
Fil: Abdelgawad, Azza. Leibniz Institute For Zoo And Wildlife Research; Alemania
dc.description.fil
Fil: Damiani, Armando Mario. Freie University Berlin; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Ho, Simón Y. W.. University of Sydney; Australia
dc.description.fil
Fil: Strauss, Gunter. Tierpark Berlin-Friedrichsfelde; Alemania
dc.description.fil
Fil: Szentiks, Claudia A.. Leibniz Institute For Zoo And Wildlife Research; Alemania
dc.description.fil
Fil: East, Marion L.. Leibniz Institute For Zoo And Wildlife Research; Alemania
dc.description.fil
Fil: Osterrieder, Nikolaus. Freie University Berlin; Alemania
dc.description.fil
Fil: Alex Greenwood. Leibniz Institute For Zoo And Wildlife Research; Alemania. Freie University Berlin; Alemania
dc.journal.title
Viruses
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/v8090262
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.mdpi.com/1999-4915/8/9/262
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