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dc.contributor.author
Perez Perez, Antonio
dc.contributor.author
Guadix, P.
dc.contributor.author
Maymo, Julieta Lorena
dc.contributor.author
Dueñas, Jose Luis
dc.contributor.author
Varone, Cecilia Laura
dc.contributor.author
Sanchez Margalet, M
dc.contributor.author
Sanchez Margalet, V.
dc.date.available
2018-06-18T20:51:23Z
dc.date.issued
2015-11
dc.identifier.citation
Perez Perez, Antonio; Guadix, P.; Maymo, Julieta Lorena; Dueñas, Jose Luis; Varone, Cecilia Laura; et al.; Insulin and Leptin Signaling in Placenta from Gestational Diabetic Subjects; Georg Thieme Verlag Kg; Hormone and Metabolic Research; 48; 1; 11-2015; 62-69
dc.identifier.issn
0018-5043
dc.identifier.uri
http://hdl.handle.net/11336/49150
dc.description.abstract
Insulin and leptin receptors are known to share signaling pathways, such as JAK2/STAT-3 (Janus kinase2/signal transduction and activator of transcription3), MAPK (Mitogen activated protein kinase), and PI3K (phosphoinositide 3-kinase). Both positive and negative cross-talk have been previously found in different cellular systems. Gestational diabetes (GDM) is a pathophysiological state with high circulating levels of both insulin and leptin. We have previously found that these 3 signaling pathways are activated in placenta from GDM patients to promote translation, involving the activation of leptin receptor. Now, we have tested the hypothesis that both leptin and insulin receptors might contribute to this activation in a positive way that may become negative when the system is overactivated. We studied the activation of leptin and insulin receptors in placenta from GDM and healthy pregnancies. We have also performed in vitro studies with insulin and leptin stimulation of trophoblast explants from healthy placenta. We have found that both leptin and insulin receptors are activated in placenta from GDM. In vitro stimulation of trophoblast explants with both leptin and insulin at submaximal doses (0.1 nM) potentiated the activation of signaling, whereas preincubation with maximal concentrations of insulin (10 nM) and further stimulation with leptin showed negative effect. Trophoblastic explants from GDM placenta, which presented high signaling levels, had a negative signaling effect when further incubated in vitro with leptin. In conclusion, insulin and leptin receptors have positive effects on signaling, contributing to high signaling levels in GDM placenta, but insulin and leptin have negative effects upon overstimulation.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Georg Thieme Verlag Kg
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Gestational Diabetes
dc.subject
Insulin
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Leptin
dc.subject
Placenta
dc.subject
Signal Transduction
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Insulin and Leptin Signaling in Placenta from Gestational Diabetic Subjects
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-07T20:04:20Z
dc.journal.volume
48
dc.journal.number
1
dc.journal.pagination
62-69
dc.journal.pais
Alemania
dc.description.fil
Fil: Perez Perez, Antonio. Hospital Virgen Macarena; España
dc.description.fil
Fil: Guadix, P.. Hospital Virgen Macarena; España. Hospital Virgen Macarena; España
dc.description.fil
Fil: Maymo, Julieta Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
dc.description.fil
Fil: Dueñas, Jose Luis. Departamento de Bioquímica Médica y Biología Molecular; España
dc.description.fil
Fil: Varone, Cecilia Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
dc.description.fil
Fil: Sanchez Margalet, M. IVI Sevilla; España
dc.description.fil
Fil: Sanchez Margalet, V.. Hospital Virgen Macarena; España
dc.journal.title
Hormone and Metabolic Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1055/s-0035-1559722
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.thieme-connect.de/DOI/DOI?10.1055/s-0035-1559722


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