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dc.contributor.author Perez Perez, Antonio
dc.contributor.author Guadix, P.
dc.contributor.author Maymo, Julieta Lorena
dc.contributor.author Dueñas, Jose Luis
dc.contributor.author Varone, Cecilia Laura
dc.contributor.author Sanchez Margalet, M
dc.contributor.author Sanchez Margalet, V.
dc.date.available 2018-06-18T20:51:23Z
dc.date.issued 2015-11
dc.identifier.citation Perez Perez, Antonio; Guadix, P.; Maymo, Julieta Lorena; Dueñas, Jose Luis; Varone, Cecilia Laura; et al.; Insulin and Leptin Signaling in Placenta from Gestational Diabetic Subjects; Georg Thieme Verlag Kg; Hormone and Metabolic Research; 48; 1; 11-2015; 62-69
dc.identifier.issn 0018-5043
dc.identifier.uri http://hdl.handle.net/11336/49150
dc.description.abstract Insulin and leptin receptors are known to share signaling pathways, such as JAK2/STAT-3 (Janus kinase2/signal transduction and activator of transcription3), MAPK (Mitogen activated protein kinase), and PI3K (phosphoinositide 3-kinase). Both positive and negative cross-talk have been previously found in different cellular systems. Gestational diabetes (GDM) is a pathophysiological state with high circulating levels of both insulin and leptin. We have previously found that these 3 signaling pathways are activated in placenta from GDM patients to promote translation, involving the activation of leptin receptor. Now, we have tested the hypothesis that both leptin and insulin receptors might contribute to this activation in a positive way that may become negative when the system is overactivated. We studied the activation of leptin and insulin receptors in placenta from GDM and healthy pregnancies. We have also performed in vitro studies with insulin and leptin stimulation of trophoblast explants from healthy placenta. We have found that both leptin and insulin receptors are activated in placenta from GDM. In vitro stimulation of trophoblast explants with both leptin and insulin at submaximal doses (0.1 nM) potentiated the activation of signaling, whereas preincubation with maximal concentrations of insulin (10 nM) and further stimulation with leptin showed negative effect. Trophoblastic explants from GDM placenta, which presented high signaling levels, had a negative signaling effect when further incubated in vitro with leptin. In conclusion, insulin and leptin receptors have positive effects on signaling, contributing to high signaling levels in GDM placenta, but insulin and leptin have negative effects upon overstimulation.
dc.format application/pdf
dc.language.iso eng
dc.publisher Georg Thieme Verlag Kg
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject GESTATIONAL DIABETES
dc.subject INSULIN
dc.subject LEPTIN
dc.subject PLACENTA
dc.subject SIGNAL TRANSDUCTION
dc.subject.classification Otras Ciencias Biológicas
dc.subject.classification Ciencias Biológicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.title Insulin and Leptin Signaling in Placenta from Gestational Diabetic Subjects
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-06-07T20:04:20Z
dc.journal.volume 48
dc.journal.number 1
dc.journal.pagination 62-69
dc.journal.pais Alemania
dc.description.fil Fil: Perez Perez, Antonio. Hospital Virgen Macarena; España
dc.description.fil Fil: Guadix, P.. Hospital Virgen Macarena; España. Hospital Virgen Macarena; España
dc.description.fil Fil: Maymo, Julieta Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
dc.description.fil Fil: Dueñas, Jose Luis. Departamento de Bioquímica Médica y Biología Molecular; España
dc.description.fil Fil: Varone, Cecilia Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
dc.description.fil Fil: Sanchez Margalet, M. IVI Sevilla; España
dc.description.fil Fil: Sanchez Margalet, V.. Hospital Virgen Macarena; España
dc.journal.title Hormone and Metabolic Research
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1055/s-0035-1559722
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://www.thieme-connect.de/DOI/DOI?10.1055/s-0035-1559722
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    Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES

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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)