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Artículo

Insulin and Leptin Signaling in Placenta from Gestational Diabetic Subjects

Perez Perez, Antonio; Guadix, P.; Maymo, Julieta LorenaIcon ; Dueñas, Jose Luis; Varone, Cecilia LauraIcon ; Sanchez Margalet, M; Sanchez Margalet, V.
Fecha de publicación: 11/2015
Editorial: Georg Thieme Verlag Kg
Revista: Hormone and Metabolic Research
ISSN: 0018-5043
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Biológicas

Resumen

Insulin and leptin receptors are known to share signaling pathways, such as JAK2/STAT-3 (Janus kinase2/signal transduction and activator of transcription3), MAPK (Mitogen activated protein kinase), and PI3K (phosphoinositide 3-kinase). Both positive and negative cross-talk have been previously found in different cellular systems. Gestational diabetes (GDM) is a pathophysiological state with high circulating levels of both insulin and leptin. We have previously found that these 3 signaling pathways are activated in placenta from GDM patients to promote translation, involving the activation of leptin receptor. Now, we have tested the hypothesis that both leptin and insulin receptors might contribute to this activation in a positive way that may become negative when the system is overactivated. We studied the activation of leptin and insulin receptors in placenta from GDM and healthy pregnancies. We have also performed in vitro studies with insulin and leptin stimulation of trophoblast explants from healthy placenta. We have found that both leptin and insulin receptors are activated in placenta from GDM. In vitro stimulation of trophoblast explants with both leptin and insulin at submaximal doses (0.1 nM) potentiated the activation of signaling, whereas preincubation with maximal concentrations of insulin (10 nM) and further stimulation with leptin showed negative effect. Trophoblastic explants from GDM placenta, which presented high signaling levels, had a negative signaling effect when further incubated in vitro with leptin. In conclusion, insulin and leptin receptors have positive effects on signaling, contributing to high signaling levels in GDM placenta, but insulin and leptin have negative effects upon overstimulation.
Palabras clave: Gestational Diabetes , Insulin , Leptin , Placenta , Signal Transduction
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/49150
DOI: http://dx.doi.org/10.1055/s-0035-1559722
URL: https://www.thieme-connect.de/DOI/DOI?10.1055/s-0035-1559722
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Articulos(IQUIBICEN)
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Citación
Perez Perez, Antonio; Guadix, P.; Maymo, Julieta Lorena; Dueñas, Jose Luis; Varone, Cecilia Laura; et al.; Insulin and Leptin Signaling in Placenta from Gestational Diabetic Subjects; Georg Thieme Verlag Kg; Hormone and Metabolic Research; 48; 1; 11-2015; 62-69
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