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dc.contributor.author
Parmeciano Di Noto, Gisela Paula
dc.contributor.author
Jara, Eugenio
dc.contributor.author
Iriarte Odini, Andrés
dc.contributor.author
Centron, Daniela
dc.contributor.author
Quiroga, Cecilia
dc.date.available
2018-06-11T22:22:31Z
dc.date.issued
2016-08
dc.identifier.citation
Parmeciano Di Noto, Gisela Paula; Jara, Eugenio; Iriarte Odini, Andrés; Centron, Daniela; Quiroga, Cecilia; Genome analysis of a clinical isolate of Shewanella sp. uncovered an active hybrid integrative and conjugative element carrying an integron platform inserted in a novel genomic locus; Society for General Microbiology; Microbiology-UK; 162; 8; 8-2016; 1335-1345
dc.identifier.issn
1350-0872
dc.identifier.uri
http://hdl.handle.net/11336/48228
dc.description.abstract
Shewanella spp. are currently considered emerging pathogens that can code for a blaOXA carbapenemase in their chromosome. Complete genome analysis of the clinical isolate Shewanella sp. Sh95 revealed that this strain is a novel species that shares a lineage with marine isolates. Characterization of its resistome showed that it codes for genes drfA15, qacH and blaOXA-48. We propose that Shewanella sp. Sh95 acts as reservoir of blaOXA-48. Moreover, mobilome analysis showed that it contains a novel ICE, named ICESh95. Comparative analysis between the close relatives ICESpuPO1 from Shewanella sp. W3-18-1 and ICE SXTMO10 from Vibrio cholerae showed that ICESh95 encompassed two new regions, a type III restriction modification system and a multidrug resistance integron. The integron platform contained a novel arrangement formed by gene cassettes drfA15 and qacH and a class C-attC group II intron. Furthermore, insertion of ICESh95 occurred at a unique target site, which correlates with the presence of a different xis/int module. Mobility of ICESh95 was assessed showing its ability to self-transfer at high levels to different bacteria species. The presence of a highly adaptable element capable of acquiring antibiotic resistance determinants, combined with its efficient activity to self-transfer makes this element a clear threat for the control of the dissemination of antimicrobial resistance; a troublesome scenario when natural bacteria from water ecosystems, such as Shewanella, act as vector in its propagation.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Society for General Microbiology
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Integrative Conjugative Element
dc.subject
Antimicrobial Resistance
dc.subject
Horizontal Transfer Events
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.subject.classification
Ciencias de la Computación
dc.subject.classification
Ciencias de la Computación e Información
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Genome analysis of a clinical isolate of Shewanella sp. uncovered an active hybrid integrative and conjugative element carrying an integron platform inserted in a novel genomic locus
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-06T13:37:30Z
dc.identifier.eissn
1465-2080
dc.journal.volume
162
dc.journal.number
8
dc.journal.pagination
1335-1345
dc.journal.pais
Reino Unido
dc.description.fil
Fil: Parmeciano Di Noto, Gisela Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
dc.description.fil
Fil: Jara, Eugenio. Universidad de la República. Facultad de Ciencias; Uruguay
dc.description.fil
Fil: Iriarte Odini, Andrés. Universidad de la República. Facultad de Ciencias; Uruguay
dc.description.fil
Fil: Centron, Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
dc.description.fil
Fil: Quiroga, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
dc.journal.title
Microbiology-UK
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1099/mic.0.000310
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://mic.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.000310


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