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dc.contributor.author
Ramirez, Maria Soledad
dc.contributor.author
Xie, Gang
dc.contributor.author
Traglia, German Matias
dc.contributor.author
Johnson, Shannon L.
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Davenport, Karen W.
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Van Duin, David
dc.contributor.author
Ramazani, Azam
dc.contributor.author
Perez, Federico
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Jacobs, Michael R.
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Sherratt, David J.
dc.contributor.author
Bonomo, Robert A.
dc.contributor.author
Chain, Patrick S. G.
dc.contributor.author
Tolmasky, Marcelo E.
dc.date.available
2018-06-08T17:10:56Z
dc.date.issued
2016-06
dc.identifier.citation
Ramirez, Maria Soledad; Xie, Gang; Traglia, German Matias; Johnson, Shannon L.; Davenport, Karen W.; et al.; Whole-Genome Comparative Analysis of Two Carbapenem-Resistant ST-258 Klebsiella pneumoniae Strains Isolated during a North-Eastern Ohio Outbreak: Differences within the High Heterogeneity Zones; Oxford Journal; Genome Biology and Evolution; 8; 6; 6-2016; 2036-2043
dc.identifier.issn
1759-6653
dc.identifier.uri
http://hdl.handle.net/11336/47880
dc.description.abstract
Klebsiella pneumoniae has become one of the most dangerous causative agents of hospital infections due to the acquisition of resistance to carbapenems, one of the last resort families of antibiotics. Resistance is usually mediated by carbapenemases coded for by different classes of genes. A prolonged outbreak of carbapenem-resistant K. pneumoniae infections has been recently described in northeastern Ohio. Most strains isolated from patients during this outbreak belong to MLST sequence type 258 (ST258). To understand more about this outbreak two isolates (strains 140 and 677), one of them responsible for a fatal infection, were selected for genome comparison analyses. Whole genome map and sequence comparisons demonstrated that both strains are highly related showing 99% average nucleotide identity. However, the genomes differ at the so-called high heterogeneity zone (HHZ) and other minor regions. This study identifies the potential value of the HHZ as a potential marker for K. pneumoniae clinical and epidemiological studies.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Oxford Journal
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Whole Genome Mapping
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Optical Map
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St-258
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Carbapenem
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Kpc
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Whole-Genome Comparative Analysis of Two Carbapenem-Resistant ST-258 Klebsiella pneumoniae Strains Isolated during a North-Eastern Ohio Outbreak: Differences within the High Heterogeneity Zones
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-06T13:37:38Z
dc.journal.volume
8
dc.journal.number
6
dc.journal.pagination
2036-2043
dc.journal.pais
Reino Unido
dc.journal.ciudad
Oxford
dc.description.fil
Fil: Ramirez, Maria Soledad. California State University Fullerton; Estados Unidos
dc.description.fil
Fil: Xie, Gang. Los Alamos National High Magnetic Field Laboratory; Estados Unidos
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Fil: Traglia, German Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
dc.description.fil
Fil: Johnson, Shannon L.. Los Alamos National High Magnetic Field Laboratory; Estados Unidos
dc.description.fil
Fil: Davenport, Karen W.. Los Alamos National High Magnetic Field Laboratory; Estados Unidos
dc.description.fil
Fil: Van Duin, David. University of North Carolina; Estados Unidos
dc.description.fil
Fil: Ramazani, Azam. California State University Fullerton; Estados Unidos. University of Oxford; Reino Unido
dc.description.fil
Fil: Perez, Federico. Louis Stokes Cleveland Department of Veterans Affairs Medical Center; Estados Unidos
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Fil: Jacobs, Michael R.. Case Western Reserve University School of Medicine; Estados Unidos
dc.description.fil
Fil: Sherratt, David J.. University of Oxford; Reino Unido
dc.description.fil
Fil: Bonomo, Robert A.. Louis Stokes Cleveland Department of Veterans Affairs Medical Center; Estados Unidos. Case Western Reserve University School of Medicine; Estados Unidos
dc.description.fil
Fil: Chain, Patrick S. G.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
dc.description.fil
Fil: Tolmasky, Marcelo E.. California State University Fullerton; Estados Unidos
dc.journal.title
Genome Biology and Evolution
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1093/gbe/evw135
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/gbe/article/8/6/2036/2574118
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