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Artículo

Whole-Genome Comparative Analysis of Two Carbapenem-Resistant ST-258 Klebsiella pneumoniae Strains Isolated during a North-Eastern Ohio Outbreak: Differences within the High Heterogeneity Zones

Ramirez, Maria SoledadIcon ; Xie, Gang; Traglia, German MatiasIcon ; Johnson, Shannon L.; Davenport, Karen W.; Van Duin, David; Ramazani, Azam; Perez, Federico; Jacobs, Michael R.; Sherratt, David J.; Bonomo, Robert A.; Chain, Patrick S. G.; Tolmasky, Marcelo E.
Fecha de publicación: 06/2016
Editorial: Oxford Journal
Revista: Genome Biology and Evolution
ISSN: 1759-6653
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Biológicas

Resumen

Klebsiella pneumoniae has become one of the most dangerous causative agents of hospital infections due to the acquisition of resistance to carbapenems, one of the last resort families of antibiotics. Resistance is usually mediated by carbapenemases coded for by different classes of genes. A prolonged outbreak of carbapenem-resistant K. pneumoniae infections has been recently described in northeastern Ohio. Most strains isolated from patients during this outbreak belong to MLST sequence type 258 (ST258). To understand more about this outbreak two isolates (strains 140 and 677), one of them responsible for a fatal infection, were selected for genome comparison analyses. Whole genome map and sequence comparisons demonstrated that both strains are highly related showing 99% average nucleotide identity. However, the genomes differ at the so-called high heterogeneity zone (HHZ) and other minor regions. This study identifies the potential value of the HHZ as a potential marker for K. pneumoniae clinical and epidemiological studies.
Palabras clave: Whole Genome Mapping , Optical Map , St-258 , Carbapenem , Kpc
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/47880
DOI: https://dx.doi.org/10.1093/gbe/evw135
URL: https://academic.oup.com/gbe/article/8/6/2036/2574118
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Articulos(IMPAM)
Articulos de INSTITUTO DE INVESTIGACIONES EN MICROBIOLOGIA Y PARASITOLOGIA MEDICA
Citación
Ramirez, Maria Soledad; Xie, Gang; Traglia, German Matias; Johnson, Shannon L.; Davenport, Karen W.; et al.; Whole-Genome Comparative Analysis of Two Carbapenem-Resistant ST-258 Klebsiella pneumoniae Strains Isolated during a North-Eastern Ohio Outbreak: Differences within the High Heterogeneity Zones; Oxford Journal; Genome Biology and Evolution; 8; 6; 6-2016; 2036-2043
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