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Artículo

Hepatic injury associated with Trypanosoma cruzi infection is attenuated by treatment with 15-deoxy-Δ 12,14 prostaglandin J 2

Penas, Federico NicolásIcon ; Cevey, Ágata CarolinaIcon ; Siffo, SofíaIcon ; Mirkin, Gerardo Ariel Isidoro; Goren, Nora BeatrizIcon
Fecha de publicación: 11/2016
Editorial: Academic Press Inc Elsevier Science
Revista: Experimental Parasitology
ISSN: 0014-4894
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Biológicas

Resumen

Trypanosoma cruzi, the etiological agent of Chagas´ disease, causes an intense inflammatory response in several tissues, including the liver. Since this organ is central to metabolism, its infection may be reflected in the outcome of the disease. 15-deoxy-Δ12,14 prostaglandin J2 (15dPGJ2), a natural agonist of peroxisome-proliferator activated receptor (PPAR) γ, has been shown to exert anti-inflammatory effects in the heart upon T. cruzi infection. However, its role in the restoration of liver function and reduction of liver inflammation has not been studied yet. BALB/c mice were infected with T. cruzi. The effects of in vivo treatment with 15dPGJ2 on liver inflammation and fibrosis, as well as on the GOT/GPT ratio were studied and the role of NF-κB pathway on 15dPGJ2-mediated effects was analysed. 15dPGJ2 reduced liver inflammatory infiltrates, proinflammatory enzymes and cytokines expression, restored the De Ritis ratio values to normal, reduced the deposits of interstitial and perisinusoidal collagen, reduced the expression of the pro-fibrotic cytokines and inhibited the translocation of the p65 NF-κB subunit to the nucleus. Thus, we showed that 15dPGJ2 is able to significantly reduce the inflammatory response and fibrosis and reduced enzyme markers of liver damage in mice infected with T. cruzi.
Palabras clave: Liver , Trypanosoma Cruzi , Ppar , 15 Deoxy Delta 12 , 14 Prostaglandin J2
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/47475
DOI: https://dx.doi.org/10.1016/j.exppara.2016.09.015
URL: https://www.sciencedirect.com/science/article/pii/S0014489416302090
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Articulos(IMPAM)
Articulos de INSTITUTO DE INVESTIGACIONES EN MICROBIOLOGIA Y PARASITOLOGIA MEDICA
Citación
Penas, Federico Nicolás; Cevey, Ágata Carolina; Siffo, Sofía; Mirkin, Gerardo Ariel Isidoro; Goren, Nora Beatriz; Hepatic injury associated with Trypanosoma cruzi infection is attenuated by treatment with 15-deoxy-Δ 12,14 prostaglandin J 2; Academic Press Inc Elsevier Science; Experimental Parasitology; 170; 11-2016; 100-108
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