Rapid identification of OXA-48 and OXA-163 subfamily in carbapenem resistant gram-negative bacilli with a novel immunochromatographic lateral flow assay

We assessed a novel immunochromatographic lateral flow assay for direct identification of OXA-48-like carbapenemases and accurate differentiation of allele variants with distinct substrate profiles (OXA-48 or OXA-163 subfamilies). The assay allowed rapid (less than 4 min) and reliable direct confirmation of OXA-163- and/or OXA-48-like enzymes (with 100% sensitivity and 100% specificity) from cultured colonies that were recovered from both solid medium and spiked blood culture bottles.

Palabras clave: Carbapenem-Resistant Gram-Negative Bacilli , Carbapenemases , Enterobacteriaceae , Immunochromatographic Lateral Flow Assay

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

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URI: http://hdl.handle.net/11336/47062

URL: http://jcm.asm.org/content/54/11/2832.long

DOI: http://dx.doi.org/10.1128/JCM.01175-16

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Pasteran, Fernando; Denorme, Laurence; Ote, Isabelle; Gómez, Sonia Alejandra; de Belder, Denise Gisele; et al.; Rapid identification of OXA-48 and OXA-163 subfamily in carbapenem resistant gram-negative bacilli with a novel immunochromatographic lateral flow assay; American Society for Microbiology; Journal of Clinical Microbiology; 54; 11; 8-2016; 2832-2836

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