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dc.contributor.author
Pérez, Denisa Soledad  
dc.contributor.author
Martínez, Guadalupe  
dc.contributor.author
Soraci, Alejandro Luis  
dc.contributor.author
Tapia, Maria Ofelia  
dc.date.available
2016-03-08T20:21:10Z  
dc.date.issued
2013-04  
dc.identifier.citation
Pérez, Denisa Soledad; Martínez, Guadalupe; Soraci, Alejandro Luis; Tapia, Maria Ofelia; In vitro penetration of the antibiotic fosfomycin in swine intestinal cells (IPEC J2); Radiance Research Academy; International Journal of Medical and Pharmaceutical Sciences; 4; 2; 4-2013; 6-16  
dc.identifier.issn
2231- 2188  
dc.identifier.uri
http://hdl.handle.net/11336/4689  
dc.description.abstract
Fosfomycin is an antibiotic widely used for the treatment and prevention of swine infections caused by resistant bacteria. The aim of this research was to study the penetration of fosfomycin in an in vitro model of intestinal cells (IPEC-J2 cells). Cells cultures were subjected to 580 μg/mL of calcium fosfomycin. Intracellular concentrations of the antibiotic were analyzed by HPLC MS/MS and they ranged from 23.48 to 45.81 μg/mL (Tmax: 4 h). Fosfomycin concentrations exceeded the MIC90 for the most important pathogens in swine intestinal infections (Escherichia coli: 0.50 μg/mL, Salmonella enterica subsp. Enterica: 4 μg/mL). Therefore, it is apparent that fosfomycin is an alternative for the treatment of intestinal infections in pigs  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Radiance Research Academy  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc/2.5/ar/  
dc.subject
Fosfomycin  
dc.subject
In Vitro  
dc.subject
Penetration, Ipec  
dc.subject
Intestinal Infections, Pigs  
dc.subject.classification
Ciencias Veterinarias  
dc.subject.classification
Ciencias Veterinarias  
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CIENCIAS AGRÍCOLAS  
dc.title
In vitro penetration of the antibiotic fosfomycin in swine intestinal cells (IPEC J2)  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2016-03-30 10:35:44.97925-03  
dc.journal.volume
4  
dc.journal.number
2  
dc.journal.pagination
6-16  
dc.journal.pais
India  
dc.journal.ciudad
Nagpur  
dc.conicet.avisoEditorial
The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.  
dc.description.fil
Fil: Pérez, Denisa Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina  
dc.description.fil
Fil: Martínez, Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina  
dc.description.fil
Fil: Soraci, Alejandro Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina  
dc.description.fil
Fil: Tapia, Maria Ofelia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina  
dc.journal.title
International Journal of Medical and Pharmaceutical Sciences  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.scopemed.org/?mno=48472  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/issn/2231- 2188  

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