Artículo
In vitro penetration of the antibiotic fosfomycin in swine intestinal cells (IPEC J2)
Fecha de publicación:
04/2013
Editorial:
Radiance Research Academy
Revista:
International Journal of Medical and Pharmaceutical Sciences
ISSN:
2231- 2188
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Fosfomycin is an antibiotic widely used for the treatment and prevention of swine infections caused by resistant bacteria. The aim of this research was to study the penetration of fosfomycin in an in vitro model of intestinal cells (IPEC-J2 cells). Cells cultures were subjected to 580 μg/mL of calcium fosfomycin. Intracellular concentrations of the antibiotic were analyzed by HPLC MS/MS and they ranged from 23.48 to 45.81 μg/mL (Tmax: 4 h). Fosfomycin concentrations exceeded the MIC90 for the most important pathogens in swine intestinal infections (Escherichia coli: 0.50 μg/mL, Salmonella enterica subsp. Enterica: 4 μg/mL). Therefore, it is apparent that fosfomycin is an alternative for the treatment of intestinal infections in pigs
Palabras clave:
Fosfomycin
,
In Vitro
,
Penetration, Ipec
,
Intestinal Infections, Pigs
Archivos asociados
Tamaño:
435.2Kb
Formato:
PDF
Licencia
Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción:
Creative Commons Attribution-NonCommercial 2.5 Unported (CC BY-NC 2.5)
Identificadores
Colecciones
Articulos(CIVETAN)
Articulos de CENTRO DE INVESTIGACION VETERINARIA DE TANDIL
Articulos de CENTRO DE INVESTIGACION VETERINARIA DE TANDIL
Citación
Pérez, Denisa Soledad; Martínez, Guadalupe; Soraci, Alejandro Luis; Tapia, Maria Ofelia; In vitro penetration of the antibiotic fosfomycin in swine intestinal cells (IPEC J2); Radiance Research Academy; International Journal of Medical and Pharmaceutical Sciences; 4; 2; 4-2013; 6-16
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