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dc.contributor.author
Pérez, Denisa Soledad
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dc.contributor.author
Soraci, Alejandro Luis
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dc.contributor.author
Tapia, Maria Ofelia
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dc.date.available
2016-03-07T20:18:49Z
dc.date.issued
2013-04
dc.identifier.citation
Pérez, Denisa Soledad; Soraci, Alejandro Luis; Tapia, Maria Ofelia; Tissue Disposition and Withdrawal Time of Fosfomycin in Swines after Oral and Intramuscular Administration; Global Researchers Journals; Journal of Animal Production Advances; 3; 4; 4-2013; 107-119
dc.identifier.issn
2251-7677
dc.identifier.uri
http://hdl.handle.net/11336/4669
dc.description.abstract
A HPLC-MS/MS method, which was suitable to be used in withdrawal time studies, was validated for the determination of fosfomycin in swine muscle, liver, kidney and skin-fat. Therefore, the withdrawal time of fosfomycin in swines, considering a MRL of 0.5 μg/mL was studied. Forty-eight pigs were assigned to two groups; in group one, fosfomycin was orally administered daily with 30 mg⁄kg bw and to the other group a dose of 15 mg⁄kg bw of the antibiotic was intramuscularly administered. Pigs were slaughtered 24, 48, 72 and 96 hours later of oral treatment withdrawn and post intramuscular treatment. The longer WDT was 2.95 days for the PO administration and 1.73 days for the IM administration; therefore, WDTs of 3 days and 2 days, respectively, could be assigned as a precautionary principle for public health, without a significant economic impact for the swine producer.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Global Researchers Journals
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Hplc Ms-Ms
dc.subject
Fosfomycin
dc.subject
Swine Tissues
dc.subject
Withdrawal Time
dc.subject.classification
Ciencias Veterinarias
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dc.subject.classification
Ciencias Veterinarias
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dc.subject.classification
CIENCIAS AGRÍCOLAS
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dc.title
Tissue Disposition and Withdrawal Time of Fosfomycin in Swines after Oral and Intramuscular Administration
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.journal.volume
3
dc.journal.number
4
dc.journal.pagination
107-119
dc.journal.pais
Turquía
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dc.journal.ciudad
Yuksekova
dc.description.fil
Fil: Pérez, Denisa Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina
dc.description.fil
Fil: Soraci, Alejandro Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina
dc.description.fil
Fil: Tapia, Maria Ofelia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina
dc.journal.title
Journal of Animal Production Advances
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.scopemed.org/?mno=32949
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.5455/japa.20130407054809
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/issn/2251-7677
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