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dc.contributor.author
Srinivas, Mangala
dc.contributor.author
Tel, Jurjen
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Schreibelt, Gerty
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Bonetto, Fernando Jose
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Cruz, Luis Javier
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Amiri, Houshang
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Heerschap, Arend
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Figdor, Carl G.
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de Vries, I. Jolanda M.
dc.date.available
2016-02-25T17:48:47Z
dc.date.issued
2015-09
dc.identifier.citation
Srinivas, Mangala; Tel, Jurjen; Schreibelt, Gerty; Bonetto, Fernando Jose; Cruz, Luis Javier; et al.; PLGA-encapsulated perfluorocarbon nanoparticles for simultaneous visualization of distinct cell populations by F MRI; Future Medicine; Nanomedicine; 10; 15; 9-2015; 2339-2348
dc.identifier.issn
1743-5889
dc.identifier.uri
http://hdl.handle.net/11336/4426
dc.description.abstract
Aim: In vivo imaging using 19F MRI is advantageous, due to its ability to quantify cell numbers, but is limited for a lack of suitable labels. Here, we formulate two stable and clinically applicable labels for tracking two populations of primary human dendritic cells (DCs) simultaneously. Materials & methods: Plasmacytoid and myeloid DCs are able to take up sufficient nanoparticles (200 nm) for imaging (1012 19F's per cell), despite being relatively nonphagocytic. Results: Clinically relevant numbers of labeled DCs could be imaged in about 10 min, even on a clinical scanner. Conclusion: We demonstrate the use of perfluorocarbon nanoparticles for simultaneous 19F MRI of distinct cell populations in a clinical setting, without spectroscopic imaging.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Future Medicine
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Perfluorocarbons
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19f Mri
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Fluorescence
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Cell Therapy
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In-Vivo Imaging.
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Biotecnología relacionada con la Salud
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dc.subject.classification
Biotecnología de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
PLGA-encapsulated perfluorocarbon nanoparticles for simultaneous visualization of distinct cell populations by F MRI
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.journal.volume
10
dc.journal.number
15
dc.journal.pagination
2339-2348
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Srinivas, Mangala. Radboud University Medical Center. Radboud Institute for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos
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Fil: Tel, Jurjen. Radboud University Medical Center. Radboud Institute for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos
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Fil: Schreibelt, Gerty. Radboud University Medical Center. Radboud Institute for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos
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Fil: Bonetto, Fernando Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Física del Litoral; Argentina
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Fil: Cruz, Luis Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Física del Litoral; Argentina
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Fil: Amiri, Houshang. Radboud University Medical Center. Department of Radiology; Países Bajos. Kerman University of Medical Sciences. Institute of Neuropharmacology. Neuroscience Research Center; Irán
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Fil: Heerschap, Arend. Radboud University Medical Center. Department of Radiology; Países Bajos
dc.description.fil
Fil: Figdor, Carl G.. Radboud University Medical Center. Radboud Institute for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos
dc.description.fil
Fil: de Vries, I. Jolanda M.. Radboud University Medical Center. Radboud Institute for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos
dc.journal.title
Nanomedicine
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.futuremedicine.com/doi/abs/10.2217/NNM.15.76
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info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/doi:10.2217/nnm.15.76
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/issn/1743-5889
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