Artículo
PLGA-encapsulated perfluorocarbon nanoparticles for simultaneous visualization of distinct cell populations by F MRI
Srinivas, Mangala; Tel, Jurjen; Schreibelt, Gerty; Bonetto, Fernando Jose
; Cruz, Luis Javier; Amiri, Houshang; Heerschap, Arend; Figdor, Carl G.; de Vries, I. Jolanda M.
![Icon](/themes/CONICETDigital/images/conicet.png)
Fecha de publicación:
09/2015
Editorial:
Future Medicine
Revista:
Nanomedicine
ISSN:
1743-5889
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Aim: In vivo imaging using 19F MRI is advantageous, due to its ability to quantify cell numbers, but is limited for a lack of suitable labels. Here, we formulate two stable and clinically applicable labels for tracking two populations of primary human dendritic cells (DCs) simultaneously. Materials & methods: Plasmacytoid and myeloid DCs are able to take up sufficient nanoparticles (200 nm) for imaging (1012 19F's per cell), despite being relatively nonphagocytic. Results: Clinically relevant numbers of labeled DCs could be imaged in about 10 min, even on a clinical scanner. Conclusion: We demonstrate the use of perfluorocarbon nanoparticles for simultaneous 19F MRI of distinct cell populations in a clinical setting, without spectroscopic imaging.
Palabras clave:
Perfluorocarbons
,
19f Mri
,
Fluorescence
,
Cell Therapy
,
In-Vivo Imaging.
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IFIS - LITORAL)
Articulos de INST.DE FISICA DEL LITORAL
Articulos de INST.DE FISICA DEL LITORAL
Citación
Srinivas, Mangala; Tel, Jurjen; Schreibelt, Gerty; Bonetto, Fernando Jose; Cruz, Luis Javier; et al.; PLGA-encapsulated perfluorocarbon nanoparticles for simultaneous visualization of distinct cell populations by F MRI; Future Medicine; Nanomedicine; 10; 15; 9-2015; 2339-2348
Compartir
Altmétricas