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dc.contributor.author
Schnabel, Annegret  
dc.contributor.author
Blois, Sandra M.  
dc.contributor.author
Meint, Peter  
dc.contributor.author
Freitag, Nancy  
dc.contributor.author
Ernst, Wolfgang  
dc.contributor.author
Barrientos, Gabriela Laura  
dc.contributor.author
Conrad, Melanie L.  
dc.contributor.author
Rose, Matthias  
dc.contributor.author
Seelbach-Göbel, Birgit  
dc.date.available
2018-05-03T17:08:51Z  
dc.date.issued
2016-04  
dc.identifier.citation
Schnabel, Annegret; Blois, Sandra M.; Meint, Peter; Freitag, Nancy; Ernst, Wolfgang; et al.; Elevated systemic galectin-1 levels characterize HELLP syndrome.; Elsevier Ireland; Journal of Reproductive Immunology; 114; 4-2016; 38-43  
dc.identifier.issn
0165-0378  
dc.identifier.uri
http://hdl.handle.net/11336/43966  
dc.description.abstract
Galectin-1 (gal-1), a member of a family of conserved β-galactoside-binding proteins, has been shown to exert a key role during gestation. Though gal-1 is expressed at higher levels in the placenta from HELLP patients, it is still poorly understood whether systemic gal-1 levels also differ in HELLP patients. In the present study, we evaluated the systemic expression of gal-1, together with the angiogenic factors, placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt-1) in conjunction with HELLP syndrome severity. Systemic levels of gal-1 and sFlt-1 were elevated in patients with both early- and late-onset HELLP syndrome as compared to healthy controls. In contrast, peripheral PlGF levels were decreased in early- and late-onset HELLP. A positive correlation between systemic gal-1 levels and sFlt-1/PlGF ratios was found in early onset HELLP patients. Our results show that HELLP syndrome is associated with increased circulating levels of gal-1; integrating systemic gal-1 measurements into the diagnostic analyses of pregnant women may provide more effective prediction of HELLP syndrome development  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Ireland  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Angiogenic Factors  
dc.subject
Galectin-1  
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Hellp  
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Pregnancy  
dc.subject.classification
Inmunología  
dc.subject.classification
Medicina Básica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.subject.classification
Medicina Critica y de Emergencia  
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Medicina Clínica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Elevated systemic galectin-1 levels characterize HELLP syndrome.  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-05-03T13:57:04Z  
dc.journal.volume
114  
dc.journal.pagination
38-43  
dc.journal.pais
Irlanda  
dc.journal.ciudad
Limerick  
dc.description.fil
Fil: Schnabel, Annegret. Universitat Regensburg; Alemania  
dc.description.fil
Fil: Blois, Sandra M.. Charité-Universitätsmedizin Berlin; Alemania  
dc.description.fil
Fil: Meint, Peter. Universitat Regensburg; Alemania  
dc.description.fil
Fil: Freitag, Nancy. Charité-Universitätsmedizin Berlin; Alemania  
dc.description.fil
Fil: Ernst, Wolfgang. Universitat Regensburg; Alemania  
dc.description.fil
Fil: Barrientos, Gabriela Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Charité-Universitätsmedizin Berlin; Alemania  
dc.description.fil
Fil: Conrad, Melanie L.. Charité-Universitätsmedizin Berlin; Alemania  
dc.description.fil
Fil: Rose, Matthias. Charité-Universitätsmedizin Berlin; Alemania  
dc.description.fil
Fil: Seelbach-Göbel, Birgit. Universitat Regensburg; Alemania  
dc.journal.title
Journal of Reproductive Immunology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jri.2016.02.002  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0165037815300735