Artículo
Elevated systemic galectin-1 levels characterize HELLP syndrome.
Schnabel, Annegret; Blois, Sandra M.; Meint, Peter; Freitag, Nancy; Ernst, Wolfgang; Barrientos, Gabriela Laura
; Conrad, Melanie L.; Rose, Matthias; Seelbach-Göbel, Birgit
Fecha de publicación:
04/2016
Editorial:
Elsevier Ireland
Revista:
Journal of Reproductive Immunology
ISSN:
0165-0378
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Galectin-1 (gal-1), a member of a family of conserved β-galactoside-binding proteins, has been shown to exert a key role during gestation. Though gal-1 is expressed at higher levels in the placenta from HELLP patients, it is still poorly understood whether systemic gal-1 levels also differ in HELLP patients. In the present study, we evaluated the systemic expression of gal-1, together with the angiogenic factors, placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt-1) in conjunction with HELLP syndrome severity. Systemic levels of gal-1 and sFlt-1 were elevated in patients with both early- and late-onset HELLP syndrome as compared to healthy controls. In contrast, peripheral PlGF levels were decreased in early- and late-onset HELLP. A positive correlation between systemic gal-1 levels and sFlt-1/PlGF ratios was found in early onset HELLP patients. Our results show that HELLP syndrome is associated with increased circulating levels of gal-1; integrating systemic gal-1 measurements into the diagnostic analyses of pregnant women may provide more effective prediction of HELLP syndrome development
Palabras clave:
Angiogenic Factors
,
Galectin-1
,
Hellp
,
Pregnancy
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Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Schnabel, Annegret; Blois, Sandra M.; Meint, Peter; Freitag, Nancy; Ernst, Wolfgang; et al.; Elevated systemic galectin-1 levels characterize HELLP syndrome.; Elsevier Ireland; Journal of Reproductive Immunology; 114; 4-2016; 38-43
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