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dc.contributor.author
Schindewolf, Craig  
dc.contributor.author
Kim, Dongwook  
dc.contributor.author
Bel, Andrea Liliana  
dc.contributor.author
Rotstein, Horacio  
dc.date.available
2018-05-02T13:30:14Z  
dc.date.issued
2016-06-20  
dc.identifier.citation
Schindewolf, Craig; Kim, Dongwook; Bel, Andrea Liliana; Rotstein, Horacio; Complex patterns in networks of hyperexcitable neurons; Elsevier Science; Theoretical Computer Science; 633; 20-6-2016; 71-82  
dc.identifier.issn
0304-3975  
dc.identifier.uri
http://hdl.handle.net/11336/43791  
dc.description.abstract
Complex patterns in neuronal networks emerge from the cooperative activity of the participating neurons, synaptic connectivity and network topology. Several neuron types exhibit complex intrinsic dynamics due to the presence of nonlinearities and multiple time scales. In this paper we extend previous work on hyperexcitability of neuronal networks, a hallmark of epileptic brain seizure generation, which results from the net imbalance between excitation and inhibition and the ability of certain neuron types to exhibit abrupt transitions between low and high firing frequency regimes as the levels of recurrent AMPA excitation change. We examine the effect of different topologies and connection delays on the hyperexcitability phenomenon in networks having recurrent synaptic AMPA (fast) excitation (in the absence of synaptic inhibition) and demonstrate the emergence of additional time scales.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Science  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Neuronal Networks  
dc.subject
Synchronization  
dc.subject.classification
Ciencias de la Computación  
dc.subject.classification
Ciencias de la Computación e Información  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Complex patterns in networks of hyperexcitable neurons  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-04-26T15:09:02Z  
dc.journal.volume
633  
dc.journal.pagination
71-82  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Schindewolf, Craig. New Jersey Institute of Technology; Estados Unidos  
dc.description.fil
Fil: Kim, Dongwook. New Jersey Institute of Technology; Estados Unidos  
dc.description.fil
Fil: Bel, Andrea Liliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Matemática; Argentina  
dc.description.fil
Fil: Rotstein, Horacio. New Jersey Institute of Technology; Estados Unidos  
dc.journal.title
Theoretical Computer Science  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0304397515005162  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.tcs.2015.05.051