Artículo
Sclerotium rolfsii scleroglucan: The promising behavior of a natural polysaccharide as a drug delivery vehicle, suspension stabilizer and emulsifier
Viñarta, Silvana Carolina
; Francois, Nora; Daraio, Marta Edit; Castellanos, Lucia Ines
; Fariña, Julia Ines
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Fecha de publicación:
08/2007
Editorial:
Elsevier Science
Revista:
International Journal of Biological Macromolecules
ISSN:
0141-8130
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Gel matrices of scleroglucans from Sclerotium rolfsii ATCC 201126 (EPS I and EPS II, from 48-h and 72-h fermentations, respectively) were evaluated on their release kinetics of theophylline (Th). Equivalent polymer (2%, w/w) and Th (0.2%, w/w) concentrations showed almost coincident drug release patterns, independently of polymer molecular weight or the microstructural properties of gel matrices. Dynamic rheological studies of scleroglucan hydrogel structures (storage, G , and loss, G, moduli) indicated a solid-like behavior. Differences on pore size dimensions (EPS I = 20m and EPS II = 7m) were in accordance to the differences in G (EPS I = 113 Pa and EPS II = 161 Pa), a fact likely related to variations in the cross-linking density of polymer networks. Compared to already known biopolymers, EPS I and EPS II at 0.5 g/L showed a good dispersing ability against particulate suspensions of activated charcoal, bentonite, CaCO3, celite and quartz powder. Emulsifying ability of both EPSs at 2 g/L was high (E = 56?60%) when tested with kerosene, moderate (∼30%) with hexadecane, and negligible in the presence of olive oil-in-water emulsions.
Palabras clave:
Scleroglucans
,
Sclerotium Rolfsii
,
Hydrogel
,
Suspensions
,
Drug Release
,
Emulsions
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(PROIMI)
Articulos de PLANTA PILOTO DE PROC.IND.MICROBIOLOGICOS (I)
Articulos de PLANTA PILOTO DE PROC.IND.MICROBIOLOGICOS (I)
Citación
Viñarta, Silvana Carolina; Francois, Nora; Daraio, Marta Edit; Castellanos, Lucia Ines; Fariña, Julia Ines; Sclerotium rolfsii scleroglucan: The promising behavior of a natural polysaccharide as a drug delivery vehicle, suspension stabilizer and emulsifier; Elsevier Science; International Journal of Biological Macromolecules; 41; 3; 8-2007; 314-323
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