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Artículo

Lack of nitric oxide-mediated regulation of amylase secretion stimulated by VIP in parotid glands of NOD mice

Roca, Valeria InesIcon ; Rosignoli, Florencia; Calafat, Mario JoseIcon ; Perez Leiros, ClaudiaIcon
Fecha de publicación: 12/2004
Editorial: Elsevier Science
Revista: International Immunopharmacology
ISSN: 1567-5769
e-ISSN: 1878-1705
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Farmacología y Farmacia

Resumen

The non-obese diabetic (NOD) mouse is chosen among other experimental models to study autoimmune sialadenitis resembling Sjögren's syndrome (SS), because of its unique characteristic of developing salivary dysfunction. Based on the deep loss of nitric oxide synthase (NOS) activity in parotid glands of NOD mice observed from early stages of disease and the inhibitory effect of nitric oxide (NO) donors on amylase secretion in normal salivary glands, our goal was to investigate whether parotid glands from NOD mice lacking NOS activity presented this regulatory mechanism of amylase secretion. We found that parotid glands from NOD mice lack nitric oxide-mediated regulation of amylase secretion in response to VIP stimulation. The lack of regulation might be assigned to the loss of NOS activity as derived from the results with NOS inhibitors and increasing concentrations of VIP. These functional differences observed in NOD vs. BALB/c parotid glands occur in the absence of immune infiltrates in exocrine tissue, and it is not related to cAMP accumulation. NO-mediated regulation of amylase secretion was not observed in BALB/c submandibular glands to the same extent as described in parotid glands and was absent in submandibular glands of NOD mice.
Palabras clave: Nod Mice , Parotid Glands , Nitric Oxide Synthase
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/43076
URL: https://www.sciencedirect.com/science/article/pii/S1567576904002589
DOI: http://dx.doi.org/10.1016/j.intimp.2004.08.004
Colecciones
Articulos(IIBBA)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Articulos(IQUIBICEN)
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Citación
Roca, Valeria Ines; Rosignoli, Florencia; Calafat, Mario Jose; Perez Leiros, Claudia; Lack of nitric oxide-mediated regulation of amylase secretion stimulated by VIP in parotid glands of NOD mice; Elsevier Science; International Immunopharmacology; 4; 14; 12-2004; 1837-1844
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