Artículo

Synthesis and characterization of new related substances of the antiarrhythmic drug dronedarone hydrochloride

Santos, Marina; Garcia, Lia Cynthia; Checura, Cintia Carolina; Gandolfi Donadío, LucíaIcon ; Fernandez, Carlos; Orgueira, Hernán; Comin, Maria JulietaIcon
Fecha de publicación: 10/2015
Editorial: Elsevier Science
Revista: Journal of Pharmaceutical and Biomedical Analysis
ISSN: 0731-7085
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

Two new potential impurities of antiarrhythmic drug substance Dronedarone Hydrochloride together with debutyldronedarone were detected by LC?MS analysis during process development. A successful synthetic strategy for the synthesis of these potential impurities was developed facilitating the access to new impurity reference standards. Their synthesis and characterization are discussed in detail. The availability of these impurity standards allowed cost reduction through the increase of process control.
Palabras clave: Dronedarone Hydrochloride , Antiarrhythmic Drug , Related Substances , Synthesis
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/42260
DOI: http://dx.doi.org/10.1016/j.jpba.2015.06.026
URL: https://www.sciencedirect.com/science/article/pii/S0731708515300418
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Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Santos, Marina; Garcia, Lia Cynthia; Checura, Cintia Carolina; Gandolfi Donadío, Lucía; Fernandez, Carlos; et al.; Synthesis and characterization of new related substances of the antiarrhythmic drug dronedarone hydrochloride; Elsevier Science; Journal of Pharmaceutical and Biomedical Analysis; 114; 10-2015; 441-446
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