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dc.contributor.author
Uranga, Romina Maria
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dc.contributor.author
Keller, Jeffrey N.
dc.date.available
2018-04-17T14:08:49Z
dc.date.issued
2010-02
dc.identifier.citation
Uranga, Romina Maria; Keller, Jeffrey N.; Diet and Age Interactions with Regards to Cholesterol Regulation and Brain Pathogenesis; Hindawi Publishing Corporation; Current Gerontology and Geriatrics Research; 2010; 2-2010; 1-14
dc.identifier.issn
1687-7063 / 1687-7071
dc.identifier.uri
http://hdl.handle.net/11336/42242
dc.description.abstract
Cholesterol is an essential molecule for brain homeostasis; yet, hypercholesterolemia and its numerous complications are believed to play a role in promoting multiple aspects of brain pathogenesis. An ever increasing number of individuals in modern Western Society are regularly consuming diets high in fat which promote the development of hypercholesterolemia. Additionally, modern societies are becoming increasingly aged, causing a collision between increased hypercholesterolemia and increased aging, which will likely lead to the development of increased pathological conditions due to hypercholesterolemia, thereby promoting deleterious neurochemical and behavioral changes in the brain. Lastly, while beneficial in controlling cholesterol levels, the long-term use of statins itself may potentially promote adverse effects on brain homeostasis, although specifics on this remain largely unknown. This review will focus on linking the current understanding of diet-induced hypercholesterolemia (as well as statin use) to the development of oxidative stress, neurochemical alterations, and cognitive disturbances in the aging brain.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Hindawi Publishing Corporation
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Aging
dc.subject
Neurodegeneration
dc.subject
Diets
dc.subject
Brain
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Diet and Age Interactions with Regards to Cholesterol Regulation and Brain Pathogenesis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-04-12T14:25:01Z
dc.identifier.eissn
1687-7071
dc.journal.volume
2010
dc.journal.pagination
1-14
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Uranga, Romina Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
dc.description.fil
Fil: Keller, Jeffrey N.. State University of Louisiana; Estados Unidos
dc.journal.title
Current Gerontology and Geriatrics Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852598/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1155/2010/219683
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/cggr/2010/219683/
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