Artículo
Diet and Age Interactions with Regards to Cholesterol Regulation and Brain Pathogenesis
Fecha de publicación:
02/2010
Editorial:
Hindawi Publishing Corporation
Revista:
Current Gerontology and Geriatrics Research
ISSN:
1687-7063 / 1687-7071
e-ISSN:
1687-7071
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Cholesterol is an essential molecule for brain homeostasis; yet, hypercholesterolemia and its numerous complications are believed to play a role in promoting multiple aspects of brain pathogenesis. An ever increasing number of individuals in modern Western Society are regularly consuming diets high in fat which promote the development of hypercholesterolemia. Additionally, modern societies are becoming increasingly aged, causing a collision between increased hypercholesterolemia and increased aging, which will likely lead to the development of increased pathological conditions due to hypercholesterolemia, thereby promoting deleterious neurochemical and behavioral changes in the brain. Lastly, while beneficial in controlling cholesterol levels, the long-term use of statins itself may potentially promote adverse effects on brain homeostasis, although specifics on this remain largely unknown. This review will focus on linking the current understanding of diet-induced hypercholesterolemia (as well as statin use) to the development of oxidative stress, neurochemical alterations, and cognitive disturbances in the aging brain.
Palabras clave:
Aging
,
Neurodegeneration
,
Diets
,
Brain
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Articulos(INIBIBB)
Articulos de INST.DE INVEST.BIOQUIMICAS BAHIA BLANCA (I)
Articulos de INST.DE INVEST.BIOQUIMICAS BAHIA BLANCA (I)
Citación
Uranga, Romina Maria; Keller, Jeffrey N.; Diet and Age Interactions with Regards to Cholesterol Regulation and Brain Pathogenesis; Hindawi Publishing Corporation; Current Gerontology and Geriatrics Research; 2010; 2-2010; 1-14
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